The frequency of adverse reactions listed below was determined according to the following (classification of the World Health Organization): very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%: rarely not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%., including individual messages.
Amlodipine
From the central nervous system: often - headache (especially at the beginning of treatment), dizziness, fatigue, drowsiness; infrequently - general malaise, hypoesthesia, paresthesia, peripheral neuropathy, tremor, insomnia. labiletmoods, unusual dreams, increased excitability, depression, anxiety; very rarely - migraine, apathy, agitation, ataxia, amnesia, luck, increased sweating.
From the digestive system: often - nausea, pain in the abdomen; infrequently vomiting, constipation or diarrhea, flatulence, dyspepsia, anorexia, dryness of the oral mucosa, thirst; rarely - gingival hyperplasia, increased appetite; very rarely - pancreatitis, gastritis, jaundice (caused by cholestasis), hyperbilirubinemia, increased activity of "liver" transaminases, hepatitis.
From the cardiovascular system: often - a feeling of palpitations, "tides" of blood to the skin of the face; infrequent reduction of blood pressure; very rarely - fainting, shortness of breath, vasculitis, orthostatic hypotension, development or exacerbation of the course XCH, cardiac arrhythmias (including bradycardia, ventricular tachycardia and atrial fibrillation), heart attack, chest pain, pulmonary edema, swelling of the lower extremities.
From the hematopoietic and lymphatic systems: rarely - thrombocytopenic purpura, leukopenia, thrombocytopenia.
From the urinary system: infrequently - frequent urination, painful urination, nocturia; very rarely - dysuria, polyuria.
On the part of the reproductive system and mammary glands: infrequently gynecomastia, impotence.
From the respiratory system: infrequently - shortness of breath, rhinitis; very rarely - cough.
From the musculoskeletal system: infrequently muscle cramps, myalgia, arthralgia, back pain, arthrosis; rarely - myasthenia gravis.
From the skin: rarely - dermatitis; very, rarely - alopecia, xeroderma, - cold sweat, a violation of skin pigmentation.
Allergic reactions: very rarely - skin itching, rash (including erythematous, maculopapular rash, urticaria), angioedema, erythema multiforme.
From the sense organs: infrequent - ringing in the ears, diplopia, disruption of accommodation, xerophthalmia, conjunctivitis, pain in the eyes; very rarely parasymia.
From the side of metabolism: very rarely - hyperglycemia.
Other: infrequently - weight loss, weight gain, nosebleeds.
Nebivolol
From the nervous system: often: headache, dizziness, fatigue, weakness, paresthesia; infrequently: depression, bright dreams, confusion, insomnia; rarely: syncope, hallucinations, amnesia.
From the gastrointestinal tract: often: nausea, constipation / diarrhea; infrequently - flatulence, indigestion, vomiting.
From the cardiovascular system: infrequently: bradycardia, cardiac atrioventricular blockade, orthostatic hypotension, peripheral circulation disorders (cold sensation in the extremities, cyanosis), shortness of breath, heart rhythm disturbances, Raynaud's syndrome, peripheral edema, cardialgia, worsening of the course of chronic heart failure, marked decrease in blood pressure.
From the skin: infrequently: skin rash of erythematous nature, itchy skin, hyperemia of the skin; rarely: aggravation of psoriasis, alopecia:
In some cases: angioedema.
From the respiratory system: infrequently: bronchospasm (including in the absence of obstructive pulmonary disease in the anamnesis), bronchospasm in patients with bronchial asthma or airway obstruction in an anamnesis.
Other: photodermatosis, hyperhidrosis, visual impairment (dry eyes), sexual dysfunction.