Neomycin + Fluocinolone acetonide (Neomycinum + Fluocinoloni acetonidum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Aminoglycosides

Glucocorticosteroids

Included in the formulation
  • Flucinar® H
    ointment externally 
    VALEANT, LLC     Russia
    • АТХ:

    D.07.C.C.02   Fluorocinolone acetonide in combination with antibiotics

    Pharmacodynamics:Combined drug.
    Neomycin
    Antibiotic from the group of aminoglycosides. Effective depending on the dose: in a high concentration has a bactericidal effect, in low - bacteriostatic. Oppresses the synthesis of protein prokaryotes, affecting the ribosomes.
    Active against Gram-positive bacteria Actinomyces spp, Bacillus antracis, Corynebacterium diphtheriae, Clostridium spp, Staphylococcus spp, Streptococcus spp, Listeria monocytogenes, Neisseria meningitidis....; and Gram-negative microorganisms: Borrelia spp., Bordetella pertussis, Treponema pallidum, Escherichia coli, Enterobacter aerogenes, Shigella spp., Salmonella spp., Haemophilus influenzae, Proteus spp., Pasteurella multocida, Vibrio cholerae, Fusobacterium spp., Klebsiella pneumoniae, Leptospira spp.
    Active with respect to Mycobacterium tuberculosis.
    Fluconolone acetonide
    Synthetic glucocorticoid for external use. It has antiexudative, antiallergic, antipruritic, anti-inflammatory and vasoconstrictive effects. It inhibits the synthesis of prostaglandins and leukotrienes, due to inhibition of phospholipase A2 activity and reduce the release of arachidonic acid from phospholipids of cell membranes. Reduces the yield of proteolytic enzymes from lysosomes. Suppresses the mitotic activity of inflammatory mediators. With topical application, it prevents the accumulation of neutrophils,thereby reducing the number of inflammatory exudate, inhibited the release of macrophages, which leads to restriction of the source of inflammation and reduce infiltration and granulation processes.
    Pharmacokinetics:

    It is applied externally, it is not absorbed from the skin surface. Systemic action does not.

    Indications:

    It is used for the treatment of allergic dermatoses complicated with or caused by sensitive neomycin bacteria, as well as skin burns.

    ICD-10

    XII.L00-L08.L01   Impetigo

    XII.L20-L30.L20.8   Other atopic dermatitis

    XII.L20-L30.L21   Seborrheic dermatitis

    XII.L20-L30.L23   Allergic contact dermatitis

    XII.L20-L30.L24   Simple irritant contact dermatitis

    XII.L20-L30.L28.1   Scabby nodosum

    XII.L20-L30.L30.0   Coin-like eczema

    XII.L20-L30.L30.3   Infectious dermatitis

    XII.L20-L30.L30.4   Erythematous intermittence

    XII.L40-L45.L40   Psoriasis

    XII.L40-L45.L43   Lichen red flat

    XII.L50-L54.L50   Hives

    XII.L50-L54.L51.1   Bullous erythema multiforme

    XII.L50-L54.L53   Other erythematous conditions

    XII.L55-L59.L56.2   Photocontact dermatitis [berloque dermatitis]

    XII.L80-L99.L93   lupus erythematosus

    XIX.T08-T14.T14.0   Superficial injury of unspecified area of ​​the body

    XIX.T20-T32.T30   Thermal and chemical burns, unspecified

    Contraindications:

    Viral and fungal skin lesions, tuberculosis, syphilis, rosacea, perioral dermatitis.

    Individual intolerance.

    Carefully:

    Atrophic skin lesions, children younger than 2 years.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Applies from 2 years 1 time / day in limited areas of the skin.

    Outerly a thin layer on the affected skin. If necessary, an air-permeable dressing is applied for no more than 24-48 hours. The course of treatment should not exceed 2 weeks.

    The highest daily dose: 2 g.

    The highest single dose: 500 mg.

    Side effects:

    Local reactions: irritation, itching of the skin. When using ointment on the face area - telangiectasia, striae, steroid acne, alopecia.

    Allergic reactions.

    Overdose:

    Cases of overdose are not described.

    Interaction:

    Clinically significant interactions were not observed.

    Special instructions:

    It is not recommended to apply ointment to mucous membranes.

    Instructions
    Up