Flucinp ® H - combined preparat, act conditioned by components included in its composition. As a result of the combined effect of fluocinolone acetonide and neomycin, the drug inhibits the development of inflammatory-allergic skin reactions complicated by bacterial infection.
Fluocinolone is a synthetic potent glucocorticosteroid for external use. Has anti-inflammatory, antipruritic and
antiallergic, as well as vasoconstrictive properties. The mechanism of anti-inflammatory action of fluocinolone acetonide is not fully understood. It is believed that fluocinolone acetonide reduces the manifestation of the inflammatory process, inhibiting the synthesis of prostaglandins and leukotrienes by inhibiting the activity of phospholipase A2 and a decrease in the release of arachidonic acid from the cell wall phospholipids. As a result, hyperemia and exudation decrease in the lesion focus. Stabilizes cellular and subcellular, including lysosomal membranes. Reduces the yield of proteolytic enzymes from lysosomes, Reduces the permeability of membranes, reduces mitotic activity, immune responses and the release of inflammatory mediators. When exposed to the skin, the edge accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and production of lymphokines; inhibition of migration of macrophages, reduction of infiltration and granulation processes; It inhibits the phase of alteration and limits the focus of inflammation. Reduces the migration of leukocytes and lymphocytes to the area of inflammation. It inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the severity of an early immunological response.
Neomycin - an aminoglycoside antibiotic, is active against a number of gram-positive microorganisms: Gram-positive cocci - Staphylococcus spp., Streptococcus spp., (Enterococcus, faecalis); aerobic bacteria - Corynebacterium - diphtheriae, Listeria monocytogenes, Bacillus antracis, anaerobic bacteria - Clostridium spp., Actinomyces spp.; Gram-negative microorganisms: aerobic bacteria - Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Enterobacter aerogenes, Vibrio cholerae, Hemophilus influenzae, Klebsiella pneumoniae, Bordetella pertussis, Pasteurella multocida, Borellia spp., Treponema pallidum; anaerobic bacteria - Leptospira interrogans, Fusobacterium spp.; aerobic gram-negative cocci - Neisseria meningitidis; acid resistant sticks - Mycobacterium tuberculosis. The resistance of microorganisms to neomycin sulfate develops slowly and to a small extent. At low concentrations, it has a bacteriostatic effect (due to a violation of protein synthesis in microbial cells), in high concentrations bactericidal (damages the cytoplasmic membranes of the microbial cell).