Nettacine (Nettacin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNethylmycinNethylmycin
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  • Vero-Netilmicin
    solution w / m in / in 
    VEROPHARM SA     Russia
  • Nettavisk
    ointment d / eye 
    SIIFI SpA     Italy
  • Nettacine
    drops d / eye 
    SIIFI SpA     Italy
    • Dosage form: & nbspeye drops
    Composition:

    Composition per 100 ml:

    Active substance: netilmicine sulfate 0.455 g (corresponding to 0.300 g of netilmicin).

    Excipients: sodium chloride - 0,870 g, benzalkonium chloride (for vials-drops) - 0,005 g, purified water - up to 100,0 ml.

    Description:Transparent colorless or slightly yellowish solution.
    Pharmacotherapeutic group:antibiotic aminoglycoside.
    ATX: & nbsp

    J.01.G.B   Other aminoglycosides

    J.01.G.B.07   Nethylmycin

    Pharmacodynamics:

    Semisynthetic aminoglycoside antibiotic of broad spectrum of action. Communicates with 30S subunit of ribosomes and disrupts protein synthesis, preventing the formation of a complex of transport and information RNA, thus disrupting the reading of the genetic code and the formation of non-functional proteins; polyribosomes split and lose the ability to synthesize a protein. In high concentrations reduces the barrier functions of cell membranes and causes the death of microorganisms. Highly active against gram-negative microorganisms (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Citrobacter spp., Morganella morganii, Aeromonas spp., Neisseria gonorrhoeae, Salmonella spp., Shigella spp. ), as well as some Gram-positive microorganisms (Staphylococcus spp., in t.ch. resistant to others.aminoglycosides, penicillin, methicillin, some cephalosporins), some strains Streptococcus spp.

    Pharmacokinetics:

    With topical application of netilmicin, systemic absorption is low. The conducted studies show that, after a single application, the concentration of netilmicin in the lacrimal fluid is: after 5 minutes, 256 μg / ml, after 10 minutes 182 μg / ml, after 20 minutes 94 μg / ml and 27 μg / ml 1 hour after application.

    Indications:Local application for the treatment of infections of the eyelids and external parts of the eye caused by microorganisms sensitive to netilmicin.
    Contraindications:

    - individual hypersensitivity to the components of the drug and other aminoglycosides;

    - children under 3 years.

    Pregnancy and lactation:

    Use during pregnancy is contraindicated. When appointing during lactation, breastfeeding should be discontinued.

    Dosing and Administration:

    Locally. Buried in the conjunctival sac 1-2 drops 3 times a day.

    Prolonged local use of antibiotics can cause resistance of microorganisms or the occurrence of a secondary fungal infection.

    In the absence of clinical improvement over a relatively short periodperiod of time, or in case of signs of irritation or sensitization, the drug should be stopped and appropriate treatment started.

    Tube-droppers are designed for single use and can not be stored after opening.

    Side effects:

    Side effects were observed in less than 2% of patients. Registered cases of burning, itching in the eye, redness of the conjunctiva of the eye.

    Overdose:

    There is no information about drug overdose.

    Interaction:

    When topical application of Nettacin, pharmacological interactions with other drugs are insignificant. Joint use, especially local and especially intracavitary with other potential nephro- and ototoxic antibiotics, may increase the risk of side effects. Increased nephrotoxicity of aminoglycosides is facilitated by joint or prolonged use with other potentially nephrotoxic drugs, such as cisplatin, polymyxin In, colistin, biomycin, streptomycin, vancomycin, other aminoglycosides and some cephalosporins (cephaloridine) or potent diuretics, such as ethacrynic acid and furosemide.

    Special instructions:
    Effect on the ability to drive transp. cf. and fur:

    Does not affect the ability to drive vehicles, mechanisms.

    Form release / dosage:

    Eye drops 0,3%.

    Tube-dropper: 0.3 ml each preparation in a tube-dropper made of polyethylene

    low pressure. 5 tubes of intravenous drippers in the strip. 1 strip per sealed bag of polyester / aluminum / polyethylene. By 3 package together with the application in a pack of cardboard.

    Flasks-droppers: 5 ml of the drug in bottle-dropper made of polyethylene

    low pressure, ukuporennuyu polystyrene cap with punch. 1 bottle per drop together with instructions for use in a pack of cardboard.

    Packaging:Tube-dropper polyethylene (5) - packings, cellulose, contour-packs, cardboard
    bottle-dropper polyethylene (1) - packs cardboard
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    Tubes-droppers: 2 years.

    After opening the tube-dropper the drug is not subject to storage. Drip bottles: 3 years.

    After opening the vial-dropper the drug should be used within 28 days.

    Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-002024
    Date of registration:07.03.2013
    The owner of the registration certificate:SIIFI SpASIIFI SpA Italy
    Manufacturer: & nbsp
    Representation: & nbspNovaMedika, OOONovaMedika, OOORussia
    Information update date: & nbsp07.08.2015
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