From the cardiovascular system: possibly - hyperemia of the face, a feeling of heat, tachycardia, peripheral edema, lowering of blood pressure. In some patients, especially at the beginning of treatment, angina attacks may occur, which requires the withdrawal of the drug;
From the central nervous system: headache, dizziness, fatigue, drowsiness. When applying high doses of the drug, single cases of paresthesia of the extremities, tremor, visual impairment, sleep disturbance were noted;
From the gastrointestinal tract and liver: nausea, constipation, diarrhea. With prolonged use of the drug, there may be cases of increased activity of "hepatic" transaminases, the occurrence of intrahepatic cholestasis;
On the part of the hematopoiesis system: in rare cases - reversible thrombocytopenia, leukopenia, anemia;
From the urinary system: an increase in daily diuresis; in patients with renal failure - impaired renal function;
Allergic and immunopathological reactions: rarely - hives, itchy skin;
Others: with long-term use - myalgia, gynecomastia, gingival hyperplasia, hyperglycemia, edema of the lower extremities.