- With the simultaneous use of other antihypertensive drugs, as well as tricyclic antidepressants, nitrates, cimetidine, inhalational anesthetics, diuretics, the hypotensive effect of nifedipine may be enhanced.
- BCCI can further increase the negative inotropic effect of such antiarrhythmic agents as amiodarone and quinidine.
- When combining nifedipine with nitrates, tachycardia increases.
- Diltiazem inhibits the metabolism of nifedipine in the body, which may require the simultaneous administration of these drugs to reduce the dose of nifedipine
- Reduces the concentration of quinidine in the blood plasma.
- Increases the concentration of digoxin and theophylline in the blood plasma.
- Rifampicin accelerates the metabolism of nifedipine, joint use is not recommended.
- With concomitant administration with cephalosporins (eg, cefixime) may increase the concentration of cephalosporins in the blood.
- Sympathomimetics, non-steroidal anti-inflammatory drugs (suppression of prostaglandin synthesis in the kidneys and retention of sodium and liquid ions in the body), estrogens (fluid retention in the body) reduce the hypotensive effect.
- Nifedipine can displace drugs with a high degree of binding (including indirect anticoagulants - coumarin and indanedione derivatives, anticonvulsant, non-steroidal anti-inflammatory drugs, quinine, salicylates, sulfinpyrazone) from the association with proteins, which may increase their concentration in the blood plasma.
- Grapefruit juice inhibits the metabolism of nifedipine in the body, so it is contraindicated during treatment with nifedipine.
- Nifedipine is metabolized by the cytochrome P450 3A system, so simultaneous use of drugs inhibiting this system can lead to interaction of the drug and nifedipine: for example, macrolides, antiviral drugs (for example, amprenavir, indinavir, nelfinavir, ritonavir or saquinavir); antifungal agents of the azole group (ketoconazole, itraconazole or fluconazole) cause an increase in the concentration of nifedipine in the blood plasma.
- Taking into account the experience of using nimodipine BCCC, one can not exclude similar interactions with nifedipine: carbamazepine, phenobarbital can cause a decrease in the concentration of nifedipine in blood plasma; a valproic acid - Increase in the concentration of nifedipine in blood plasma.