Inside, during meals or after meals.
Adults - 100 mg 4 times a day, the maximum daily dose - 800 mg.
Average dose for children from 3 to 5 years - 50 mg each, 5 years and over - 50-100 mg 4 times a day.
The duration of treatment depends on the nature and severity of the disease.
In most cases, the course of treatment is 2-3 weeks.
Repeated courses (if necessary) are conducted with a 2-week break.
With chronic recurrent processes, the course of treatment is several months.
For the prevention of infections in kidney and urinary tract surgery - 100 mg 4 times a day for 2-3 weeks.
Correction of dose with renal failure: for patients with moderate renal failure (creatinine clearance above 20 ml / min), the usual dose should be divided in half (1 tablet 4 times a day). In severe renal failure (creatinine clearance <20 ml / min), treatment with the drug is contraindicated.
Correction of dose with hepatic insufficiency: the usual dose should be divided in half (1 tablet 4 times a day).
Do not prescribe treatment courses for more than 4 weeks without additional examination of the liver and kidney function.
Correction of dose in old age: the usual dose should be divided in half (1 tablet 4 times a day).