Nitroxoline - instructions for use, dose, side effects, contraindications

The drug inhibits the synthesis of bacterial DNA and forms complexes with metal-containing enzymes of bacterial cells, which causes the bacteriostatic effect of the drug. Also, the drug reduces adhesion Escherichia coli to the surface of the catheters and the epithelium of the urinary tract.

The drug is active against a wide range of microorganisms:

Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Klebsiella spp., Enterobacter spp., Neisseria gonorrhoeae, Staphylococcus spp., Staphylococcus aureus, Streptococcus spp., Streptococcus pneumoniae, Enterococcus faecalis, Corynebacterium, Bacillus subtilis, Mycobacterium tuberculosis, Trichomonas vaginalis, Candida spp.

Pharmacokinetics:

The drug is quickly and completely absorbed from the gastrointestinal tract. Excreted by the kidneys unchanged in large concentrations.

Indications:

Epididymitis, the prevention of infectious complications in medical and diagnostic interventions, infectious and inflammatory diseases of the urinary tract (including pyelonephritis, cystitis, urethritis),which are caused by sensitive microorganisms, infected adenoma and carcinoma of the prostate.

ICD-10

XIV.N10-N16.N10 Acute tubulointerstitial nephritis

XIV.N10-N16.N11 Chronic tubulointerstitial nephritis

XIV.N10-N16.N12 Tubulointerstitial nephritis, not specified as acute or chronic

XIV.N30-N39.N30 Cystitis

XIV.N30-N39.N34 Urethritis and urethral syndrome

XIV.N40-N51.N41 Inflammatory diseases of the prostate

XIV.N40-N51.N41.9 Inflammatory disease of prostate, unspecified

XIV.N40-N51.N45 Orchitis and epididymitis

XIV.N40-N51.N51.0 * Disorders of the prostate gland in diseases classified elsewhere

XXI.Z20-Z29.Z29.2 Another type of preventive chemotherapy

XIV.N40-N51.N40 Hyperplasia of the prostate

Contraindications:

Diseases of the liver, renal dysfunction, accompanied by oligo- or anuria, deficiency of glucose-6-phosphate dehydrogenase (high risk of hemolytic anemia), hypersensitivity, neuritis, cataract, pregnancy and lactation, polyneuritis.

Carefully:

With renal failure (cumulation is possible).

Pregnancy and lactation:

Category FDA not defined, not to be used during pregnancy and lactation.

Dosing and Administration:

Orally with meals.

Adults: 100 mg 4 times a day, the maximum daily dose is 800 mg.

Children 5 years and older: 50-100 mg 4 times a day.

Children under 5 years: 50 mg per day.

The repeated course is carried out after 2 weeks, the course of treatment for chronic recurrent infections can reach several months. For the prevention of infectious diseases during operations on the urinary tract and kidneys apply 100 mg 4 times a day for 2-3 weeks.

Side effects:

From the digestive system: nausea, vomiting, loss of appetite; in isolated cases - violations of the liver.

Allergic reactions: skin rash, itching.

From the side of the central nervous system and the peripheral nervous system: in isolated cases - ataxia, headache, paresthesia, polyneuropathy; at long application the case of development of a neuritis of an eye nerve is described.

From the cardiovascular system: in isolated cases - tachycardia.

Overdose:

Not described, treatment is symptomatic.

Interaction:

Not described.

Special instructions:

At the time of taking the drug, the urine acquires a saffron-yellow color.

Instructions

Nitroxoline (Nitroxolinum)