Nonoxynol (Nonoxinol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNonoxynolNonoxynol
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  • Nonoxynol
    suppositories the vagina. 
    Amkafarm Pharmaceutical GmbH     Germany
  • Patent Oval H
    suppositories the vagina. 
    Merz Pharma GmbH & Co. KG.KGaA     Germany
    • Dosage form: & nbspVaginal suppositories
    Composition:

    Active substance: Nonoxynol-9 -120 mg;

    Excipients: D-, L- Lactic Acid, Macrogol 4000 (polyethylene oxide), Macrogol 1000 (polyethylene oxide).
    Description:

    White or colorless homogeneous suppressor torpedo shape without visible inclusions on the longitudinal section.

    Pharmacotherapeutic group:contraceptive for topical use.
    ATX: & nbsp

    G.02.B.B   Intravaginal contraceptives

    Pharmacodynamics:

    Nonoxynol is a nonionic surface-active compound, its spermicidal effect due to fragmentation and reduction in sperm motility. Has bactericidal activity against gonococci and chlamydia. In vitro is active in relation to HIV infections, but there are no clinical data on reducing the risk of HIV infection with nonoxynol. Lactic acid has a beneficial effect on normal miklofloru and vaginal mucosa.

    When using the suppository, the concentration of nonoxinol in the vagina averages 1 to 1.7%, which is sufficient for the development of spermicidal activity.Spermicidal action of the suppository occurs after its dissolution, approximately 10 minutes after insertion into the vagina, and lasts no more than 2 hours.

    When applying the drug, foam is not formed.

    Pharmacokinetics:

    Data on the pharmacokinetics of nonoxinol in humans are absent.

    Indications:

    Local contraception.

    Contraindications:

    Hypersensitivity to the components of the drug; cervical erosion; salpingo-oophoritis; colpitis; vaginitis; abnormalities of the vaginal development, making it difficult to use the drug.

    Pregnancy and lactation:

    When pregnancy is not applied.

    Can be used for contraception during lactation.
    Dosing and Administration:The suppository is inserted into the vagina as deeply as possible, not less than 10 minutes and not earlier than 1 hour before the onset of sexual intercourse. When a second sexual intercourse is used, a new suppository is used in the same scheme. After sexual intercourse for 6 hours, not it is recommended to make the toilet of the vagina in order to avoid loss of contraceptive effect.

    Side effects:

    Rarely - dermatitis, itching, burning of the vagina of a woman or penis partner. Irritation usually occurs without taking special measures.

    Interaction:

    Because of the possible decrease in spermicidal activity, the drug Nonoxynol It is not recommended to be used with other drugs intended for intravaginal administration.

    Special instructions:

    If itching occurs, use of the drug should be discontinued.

    With frequent use of suppositories, the likelihood of side effects increases.

    Can be used in conjunction with a condom.

    Form release / dosage:

    Vaginal suppositories 120 mg.

    Packaging:

    Each package contains 10 suppositories.

    5 pieces per contour cell packaging made of polyvinyl chloride film. 2 contour packs in a cardboard box with instructions for medical use.
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N014273 / 01
    Date of registration:11.12.2008
    The owner of the registration certificate:Amkafarm Pharmaceutical GmbHAmkafarm Pharmaceutical GmbH Germany
    Manufacturer: & nbsp
    Representation: & nbspALTFARM LLC ALTFARM LLC Russia
    Information update date: & nbsp06.08.2015
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