Oleandomycin + Tetracycline - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Macrolides and Azalides

Tetracyclines

Included in the formulation

Oletketrin

pills inwards

BIOSINTEZ, PAO Russia

АТХ:

J.01.R.A Combinations of antibacterial drugs

Pharmacodynamics:

Oleandomycin

A bacteriostatic antibiotic that blocks the synthesis of the protein during the translocation stage interacts with the 50S subunit of bacterial ribosomes. The preparation disrupts the process of transferring the formed peptide from the A site to the P region by binding to a specific ligand in the ribosomal tunnel from which the resulting peptides leave. The agonist of the motilin receptors of the gastrointestinal tract (to a lesser extent than erythromycin). Oleandomycin is highly active against a number of Gram-positive cocci, including Staphylococcus spp., resistant to benzylpenicillin, tetracycline and other antibiotics.

Tetracycline

Tetracycline depresses the synthesis of proteins at the level of ribosome bacteria. Tetracyclines bind to the 30S subunit of bacterial ribosomes, blocking the binding of aminoacyl-tRNA to site A on the mRNA-ribosomal complex. As a result, the attachment of subsequent amino acids to the growing polypeptide chain is disrupted and the process of elongation of the polypeptide is suspended. Tetracyclines penetrate into Gram-negative bacteria through passive diffusion through porin proteins of the outer membrane, followed by active (energy-dependent) transport through the internal cytoplasmic membrane.Penetration into Gram-positive bacteria, such as the causative agent of anthrax, occurs in a similar manner using an energy-dependent transport system. Unlike bacteria, in mammalian cells there is no system of active transport of tetracyclines. The mechanism of penetration of tetracyclines into the cell explains the selectivity of the action of antibiotics on bacterial cells. Tetracycline - broad spectrum antibiotic with bacteriostatic action, effective against intracellular pathogens (mycoplasma, rickettsia, chlamydia), is most active against multiplying microorganisms.

The benefits of the drug also include a much slower development of resistance of microorganisms to the combination than to each of them separately.

Pharmacokinetics:

Oleandomycin: well absorbed, pThe distribution is good (except for the central nervous system). The duration of the action is 4-6 hours. Excreted by the kidneys and gastrointestinal tract.

Tetracycline: bioavailability - 75-77%, food reduces bioavailability. It is distributed in bile, pleural, synovial, ascitic, cerebrospinal fluid; accumulates in the bones, liver, spleen, teeth. The connection with plasma proteins is 60%, the half-life is 6-11 hours. Excreted by the kidneys and through the gastrointestinal tract.

Indications:

- pneumonia;

- tonsillitis;

- bronchiectatic disease;

- bronchitis;

- pyelonephritis;

- endometritis;

- erysipelas;

- infections of the urino-genital organs;

- Tularemia;

- suppurative infections of the skin and soft tissues;

- pharyngitis;

- sinusitis;

- otitis media;

- cholecystitis;

- cystitis;

- prostatitis;

- purulent meningitis;

- gonorrhea;

- brucellosis;

- osteomyelitis.

ICD-10

I.A20-A28.A21 Tularemia

I.A20-A28.A23 Brucellosis

I.A30-A49.A39 Meningococcal infection

I.A30-A49.A46 Erys

VI.G00-G09.G00 Bacterial meningitis, not elsewhere classified

VIII.H65-H75.H66 Purulent and unspecified otitis media

X.J00-J06.J00 Acute nasopharyngitis (runny nose)

X.J00-J06.J01 Acute Sinusitis

X.J00-J06.J02 Acute pharyngitis

X.J00-J06.J03 Acute tonsillitis

X.J00-J06.J04 Acute laryngitis and tracheitis

X.J10-J18.J15 Bacterial pneumonia, not elsewhere classified

X.J20-J22.J20 Acute bronchitis

X.J30-J39.J31 Chronic rhinitis, nasopharyngitis and pharyngitis

X.J30-J39.J32 Chronic Sinusitis

X.J30-J39.J35.0 Chronic tonsillitis

X.J30-J39.J37 Chronic laryngitis and laryngotracheitis

X.J40-J47.J42 Chronic bronchitis, unspecified

X.J40-J47.J47 Bronchoectasia

XII.L00-L08.L01 Impetigo

XII.L00-L08.L02 Abscess of skin, boil and carbuncle

XII.L00-L08.L03 Phlegmon

XII.L00-L08.L08.0 Pyoderma

XIII.M86-M90.M86 Osteomyelitis

XIV.N10-N16.N10 Acute tubulointerstitial nephritis

XIV.N10-N16.N11 Chronic tubulointerstitial nephritis

XIV.N30-N39.N30 Cystitis

XIV.N30-N39.N34 Urethritis and urethral syndrome

XIV.N40-N51.N41 Inflammatory diseases of the prostate

XIV.N70-N77.N70 Salpingitis and oophoritis

XIV.N70-N77.N71 Inflammatory diseases of the uterus, except the cervix

XIV.N70-N77.N72 Inflammatory disease of the cervix

Contraindications:

- hypersensitivity;

- age up to 8 years;

- leukopenia;

- mycoses;

- hepatic or renal insufficiency;

- bVariability.

Carefully:

- arrhythmias;

- lactation;

- porphyria;

- myasthenia gravis;

- prolongation of the QT interval;

- jaundice.

Pregnancy and lactation:

Category FDA not determined. The drug is contraindicated in pregnancy.

Dosing and Administration:

Orally: adults - 0.25 g 4 times a day, the maximum daily dose of 2 g; children - 20-30 mg / kg, the frequency of reception - 4 times.

Intramuscularly: adults - 0.2-0.3 g 2-3 times, children - 10-20 mg / kg.

Intravenously sprayed: adults - 0.2-0.3 g at a rate of 2 ml / min.

Intravenously drip: 0.1% solution in 0.9% saline solution or 5% dextrose solution at a rate of 60 drops per minute.

The course of treatment is 5-10 days.

Side effects:

Decreased appetite, nausea, abdominal pain, esophagitis, allergic reactions, intestinal dysbiosis, candidiasis, pseudomembranous enterocolitis, thrombocytopenia, photosensitivity, azotemia, hyperbilirubinemia, increased activity of hepatic transaminases, vitamin deficiency in the group B and K, disruption of skeletal formation, yellow or gray-brown staining and damage to the teeth.

Overdose:

Hearing loss, impaired liver function. Treatment is symptomatic.

Interaction:

Medicinal products and food products containing Ca2+, Al3+ and / or Mg2+, Fe (antacids, preparations of Fe, milk and dairy products), reduce the absorption of the drug.

Special instructions:

If the drug is prescribed during the development of the teeth, an irreversible change in their color may occur.

Impact on the ability to drive vehicles and manage mechanisms

Not found.

Instructions

Oleandomycin + Tetracycline (Oleandomycinum + Tetracyclinum)