Active substanceOxacillinOxacillin
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  • Oxacillin
    powder w / m in / in 
    BIOSINTEZ, PAO     Russia
  • Oxacillin
    powder w / m 
    BIOCHEMIST, OJSC     Russia
  • Oxacillin
    pills inwards 
    ORGANICS, JSC     Russia
  • Oxacillin
    powder w / m in / in 
    SYNTHESIS, OJSC     Russia
  • Oxacillin
    powder w / m in / in 
    SYNTHESIS, OJSC     Russia
  • Oxacillin
    powder w / m 
    SYNTHESIS, OJSC     Russia
  • Oxacillin
    powder w / m 
    KRASFARMA, JSC     Russia
  • Dosage form: & nbsppills
    Composition:

    1 tablet contains:

    active substance: oxacillin sodium salt (in terms of oxacillin) 0.25 g;

    Excipients: potato starch, calcium stearate.

    Description:

    Tablets are white in a flat-cylindrical form with a facet and a risk.

    Pharmacotherapeutic group:Antibiotic-penicillin semisynthetic
    ATX: & nbsp

    J.01.C.F.   Penicillins resistant to beta-lactamases

    J.01.C.F.04   Oxacillin

    Pharmacodynamics:

    Antibiotic from the group of semisynthetic penicillins, is resistant to the action of penicillinase. It blocks the synthesis of the bacterial cell wall by disrupting the late stages of peptidoglycan synthesis (prevents the formation of peptide bonds by inhibiting transpeptidase), causes lysis of fissile bacterial cells.

    The bactericidal action is manifested in relation to gram-positive microorganisms: Staphylococcus spp. (including those producing penicillinase), Streptococcus spp., in t.ch. Streptococcus pneumoniae, Corynebacterium diphtheriae, Bacillus anthracis, anaerobic spore-forming rods, Gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), Actinomyces spp., Treponema spp.

    He is active against most gram-negative bacteria, rickettsia, viruses, protozoa, fungi.

    Sustainability develops slowly.

    Pharmacokinetics:

    Absorption is fast and complete. It is stable in slightly acidic medium. The connection with plasma proteins is about 90%. Half-life is 30 minutes. In the pleural fluid is found in a concentration reaching 10%, synovial and ascitic fluid - 50%, bile - 5-8% in relation to its concentration in the blood serum. It does not penetrate the intact blood-brain barrier.

    Penetrates through the placental barrier, is found in breast milk. 20-30% of the drug after oral administration is rapidly excreted by the kidneys, and is also excreted with bile (10%).

    Indications:

    Infectious-inflammatory diseases caused by sensitive microorganisms: abscess, phlegmon, cholecystitis, pyelitis, cystitis, osteomyelitis, postoperative, wound infections, infected burns, bacterial endocarditis, sinusitis.

    Contraindications:

    Hypersensitivity (including other beta-lactam antibiotics), children under 3 years (for this form).

    Carefully:

    Allergic reactions in history and / or bronchial asthma, chronic renal failure, enterocolitis on the background of antibiotic use (in the anamnesis), pregnancy, lactation.

    Pregnancy and lactation:

    The use of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

    If necessary, use during lactation should stop breastfeeding.

    Dosing and Administration:

    Inside, 1 hour before meals or 2-3 hours after eating.

    Single dose for adults and children over 6 years - 0.25-0.5 g (up to 1 g), daily - 3 g. In severe infections, the doses are increased to 6-8 g / day (the daily dose is divided into 4-6 receptions).

    Children aged 3 to 6 years - 2 g / day.

    The duration of the course of treatment is 7-10 days, for severe diseases 2-3 weeks or more.

    Side effects:

    Allergic reactions: itching, hives; less often - angioedema, bronchospasm, anaphylactic shock, eosinophilia.

    From the gastrointestinal tract: dyspepsia (nausea, vomiting, diarrhea), pseudomembranous enterocolitis, candidiasis of the oral cavity, hepatotoxic effect (hyperthermia, nausea, vomiting, icterus sclera or skin), increased activity of "liver" transaminases.

    From the urinary system: hematuria, proteinuria, interstitial nephritis.

    Other: vaginal candidiasis.

    Interaction:

    Antacids and laxatives reduce absorption from the gastrointestinal tract.

    It is not recommended to prescribe concomitantly with bacteriostatic antibiotics (decreased efficacy).

    Drugs that block tubular secretion, increase the concentration of oxacillin in the blood.

    The combination of ampicillin or benzylpenicillin with oxacillin is rational, since the latter, suppressing the activity of penicillinase, reduces thereby the destruction of ampicillin and benzylpenicillin. The spectrum of action with this combination becomes wider.

    It is necessary to avoid joint use with other drugs that have a hepatotoxic effect.

    Increases the toxicity of methotrexate (competition for tubular secretion); it may be necessary to increase the doses of calcium folinate (antidote of folic acid antagonists) and its longer use.

    Special instructions:

    It is inappropriate to use in infections caused by microorganisms that are sensitive to benzylpenicillin.

    Form release / dosage:

    Tablets, 0.25 g.

    Packaging:

    20 tablets in cans of light-protective glass or in cans of polymeric.

    10 tablets in a planar cell package.

    Each jar, 1 or 2 contour mesh packages together with the instruction for use is placed in a pack of cardboard.

    Storage conditions:

    In dry, dark place at a temperature of 18 to 20 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-009627/08
    Date of registration:03.12.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.05.2017
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