The most common side effect of the gastrointestinal tract is excessive salivation, nausea, vomiting, deterioration or a loss appetite, pain in the abdomen, diarrhea, flatulence, constipation.
Allergic reactions: fever, dermatitis such as urticaria or purpura, enanthema,asthmatic phenomena, pain in the joints, eosinophilia, rarely agranulocytosis, leukopenia, thrombocytopenia, drug-induced hepatitis. Allergic reactions may appear in a few days, although they mostly arise in period between the 2nd and the 7th week of treatment (most often at 4-5 weeks). Occasionally, side effects such as severe allergic reactions (eg, Quincke's edema), swelling of the joints, fever caused by the administration of drugs, reactions similar to lupus erythematosus, accompanied by lesions of the spleen, liver, kidneys, digestive tract, bone marrow and nervous system eg, radicular pain, meningism, polymorphic exudative erythema in the form of Stevens-Johnson syndrome or syndrome Laella).
With a long course of treatment with PASC, in rare cases, there may be an increase in prothrombin time, accompanied by bleeding, and in exceptional cases - accompanied by hemorrhagic rash.
With a varying frequency (from rare to very frequent cases), a mild transient microhematuria, albuminuria and cylindruria can occur.
Crystalluria can be prevented by maintaining a neutral or alkaline pH value of urine. It is possible to increase the level of urea in the blood, indicating a presence of uremic reaction, especially in patients with impaired renal function and acidosis.
There are rare reports of a moderate transient increase in transaminase activity, sometimes accompanied by jaundice. Approximately 25% of patients who have an allergic reaction to PASC have liver damage, and in 10% cases it may lead to the onset of liver failure and death.
Often, especially when using high doses, there is a worsening of the thyroid function, accompanied by the appearance of goitre.
Rare side effects are abrupt violations of electrolyte balance, mainly in the form of hypokalemia with high doses of the drug, especially in elderly patients with edema and hypertension, as well as patients suffering from meningitis. With the introduction of large doses of the drug, the loss of cations can cause acidosis; most often it occurs in children.
Occasionally, normoglycemic or hyperglycemic glucosuria.
In some cases, a temporary (including allergic) infiltrate can be formed in the lungs (Löffler syndrome).
In some cases, there may be symptoms of paralysis, clonic-tonic convulsions, and psychosis.
With prolonged use in higher doses - hypothyroidism, goitre, superinfection.