Allergic reactions: fever, hives, purpura, enanthema, bronchospasm, joint pain, medical hepatitis. Allergic reactions may appear in a few days, although they mostly occur between the 2nd and 7th week of treatment (most often at 4-5 weeks). Quincke's edema, swelling of the joints, fever caused by the administration of drugs, lupus-like reactions, reactions accompanied by spleen, liver, kidney, digestive tract, bone marrow and nervous system (eg, radicular pain, meningism, polymorphic exudative erythema in the form of syndrome Stevens-Johnson syndrome or Lyell's syndrome).In the lungs, a temporary (including allergic) infiltrate can be formed (Leffler's syndrome).
From the gastrointestinal tract: excessive salivation, nausea, vomiting, worsening or loss of appetite, abdominal pain, diarrhea, flatulence, constipation.
From the cardiovascular system: pericarditis, vasculitis.
From the nervous system: optic neuritis, encephalopathy.
From the hematopoiesis: eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, B 12-deficiency anemia, hemolytic anemia with a positive Coombs breakdown. With a long course of treatment with aminosalicylic acid, in rare cases, an increase in prothrombin time may occur, accompanied by hemorrhagic rash or bleeding.
From the urinary system: moderate transient microhematuria, albuminuria and cylindruria, normoglycemic or hyperglycemic glucosuria. Crystalluria can be prevented by maintaining a neutral or alkaline pH value of urine. It is possible to increase the level of urea in the blood, indicating the presence of uremic reaction, especially in patients with impaired renal function and acidosis.
From the liver and bile ducts: a moderate transient increase in the activity of "liver" transaminases, sometimes accompanied by jaundice. Approximately 25% of patients with an allergic reaction to aminosalicylic acid have liver damage, and in 10% of cases it can lead to liver failure and death.
From the endocrine system: when using high doses, there is a worsening of the thyroid function, accompanied by the appearance of goiter.
Laboratory indicators: hyperbilirubinemia.
Other: syndrome resembling infectious mononucleosis or lymphoma, hypokalemia with the introduction of high doses of the drug, especially in elderly patients with edema and hypertension, as well as in patients with meningitis. With the introduction of large doses of the drug, the loss of cations can cause acidosis, especially in children. Can be observed symptoms of paralysis, tonic-clonic seizures, as well as psychosis. With prolonged use in high doses - hypothyroidism, superinfection.