Pentalgin® Plus (Pentalgin® Plus)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

Each tablet contains: active substances: propiphenazone 250 mg, paracetamol 300 mg, caffeine 50 mg, codeine phosphate 8 mg, phenobarbital 10 mg.

Excipients: aerosil, primogel (sodium carboxymethyl starch), potato starch, K25 (povidone) plasdon, microcrystalline cellulose, sodium dodecyl sulfate (sodium lauryl sulfate), stearic acid, talc.

Description:

Biconvex tablets white or white with a cream shade in the form of a capsule with flat side surfaces, with a risk on one side and an inscription PENTALGIN. another. Marble is allowed.


Pharmacotherapeutic group:Analgesic combined (analgesic opioid means + NSAIDs + psychostimulant + barbiturate)
ATX: & nbsp
  • Paracetamol
    • Pharmacodynamics:

    Combined drug, the effect of which is determined by the components that make up its composition.

    Paracetamol and propiphenazone have antipyretic, analgesic effect. Caffeine has a general tonic effect (reduces drowsiness and fatigue, increases mental and physical performance, increases the heart rate, increases blood pressure in hypotension). Codeine has an analgesic effect and improves the tolerance of pain; phenobarbital - sedative and spasmolytic action.

    Pharmacokinetics:not described
    Indications:

    Moderately pronounced pain syndrome of various genesis, including joint and muscle pain, algodismenore, neuralgia, posttraumatic pain, and headache and dental pain. Pentalgin can be used as a symptomatic remedy for febrile syndrome.


    Contraindications:

    Hypersensitivity to paracetamol, propiphenazone or other pyrazolone derivatives (metamizol sodium, phenylbutazone), as well as to other components of the drug; hepatic and / or renal insufficiency; peptic ulcer of the stomach and duodenum (in the stage of exacerbation); deficiency of glucose-6-phosphate dehydrogenase; anemia, leukopenia; conditions accompanied by respiratory depression; intracranial hypertension; arterial hypertension; alcoholism; increased excitability, insomnia; pregnancy and lactation; children's age (up to 12 years).

    Carefully:elderly age, glaucoma, bronchial asthma.
    Pregnancy and lactation:contraindicated
    Dosing and Administration:

    The drug is taken orally, usually 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets.

    The drug should not be taken more than 5 days when prescribed as an anesthetic and more than 3 days as an antipyretic. Other dosages and regimens are prescribed by the doctor.

    Side effects:

    Allergic reactions (rash, Quincke's edema, pruritus, urticaria), dizziness, palpitation, increased blood pressure, nausea, agranulocytosis, increased excitability (especially in children), decreased speed of psychomotor reactions, drowsiness.

    All side effects of the drug, including those not listed in this manual, should be reported to your doctor.

    Overdose:

    signs of acute poisoning: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia, agitation.

    If you suspect a poisoning, you should immediately seek medical help. Treatment: the affected person should do gastric lavage and prescribe adsorbents (Activated carbon).


    Interaction:

    It should be avoided combination of the drug with barbiturates, antiepileptic drugs,zidovudine, rifampicin and alcohol-containing beverages (the risk of hepatotoxic effects increases).

    Paracetamol increases the time taken for chloramphenicol 5 times. Caffeine accelerates the absorption of ergotamine. Codeine intensifies the effect of sleeping pills, analgesics and sedatives. Metoclopramide accelerates the absorption of paracetamol. At repeated reception paracetamol can enhance the effect of anticoagulants (derivatives of dicumarin).

    Special instructions:

    With prolonged (more than 5 days) use of the drug, control of the picture of peripheral blood and the functional state of the liver is necessary.

    During treatment, you should stop using alcohol-containing beverages (increased risk of gastrointestinal bleeding). Excessive consumption of caffeinated products (coffee, tea) on the background of treatment can cause symptoms of an overdose.

    Taking the drug may make it difficult to establish a diagnosis with abdominal pain syndrome, including with an "acute" abdomen. Taking the drug may change the results of the doping control tests of athletes.

    In patients with atopic bronchial asthma, pollinosis, there is an increased risk of developing hypersensitivity reactions.


    Effect on the ability to drive transp. cf. and fur:It is necessary to refrain from potentially dangerous activities requiring increased attention, because the drug slows the reaction rate and causes drowsiness.
    Form release / dosage:

    Pills. For 12 tablets in a contour mesh box made of PVC film and aluminum foil; 1 or 2 contour squares, together with instructions for use, are put in a cardboard pack.

    Storage conditions:Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
    Shelf life:

    2 years. Do not use after the expiration date. the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-002501
    Date of registration:17.06.2010 / 21.05.2015
    The owner of the registration certificate:OTISIFARM, OJSC OTISIFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp2016-01-28
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