Pentamine (Pentamin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAzamethonium bromideAzamethonium bromide
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  • Pentamine
    solution w / m in / in 
    DALHIMFARM, OJSC     Russia
  • Pentamine
    solution w / m in / in 
    NOVOSIBHIMFARM, OJSC     Russia
  • Pentamine
    solution w / m in / in 
    UZOLE-SIBERIAN CHEMICAL PLANT, OJSC     Russia
    • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:

    Azamethonium bromide (pentamine) - 50 m,

    Excipient: water for injection - up to 1 ml.
    Pharmacotherapeutic group:Ganglia-blocking agent
    Pharmacodynamics:

    Ganglioblokiruyuschee, blocks n-holinoretseptory vegetative ganglia (sympathetic and parasympathetic). Has a depressing effect on carotid glomeruli and chromaffin tissue of the adrenal glands. In large doses can block n-holinoretseptory skeletal muscle and central nervous system. Has hypotensive, arterio-and venodilating effect.

    Reduces the excretion of catecholamines by the adrenal glands and weakens reflex pressor reactions, which causes tachycardia, paresis of accommodation, mydriasis, bronchial dilatation, decreased motility of the gastrointestinal tract and glandular secretion, bladder tone.

    Indications:

    Hypertensive crisis, spasm of peripheral vessels, obliterating peripheral vascular lesions (endarteritis, atherosclerosis and others), pain syndrome with ulcer of the stomach and duodenum,intestinal colic, biliary colic, renal colic, bronchial asthma (for relief of acute attacks), eclampsia, causalgia, pulmonary edema, cerebral edema.

    In anesthesiology - for controlled arterial hypotension.

    In urological practice - with cystoscopy in men (to facilitate the passage of the cystoscope through the urethra).

    Contraindications:

    Hypersensitivity, arterial hypotension, shock, acute myocardial infarction, angle-closure glaucoma, hepatic insufficiency, chronic renal failure.

    Carefully:

    Atony of the intestine and bladder of various etiologies, thromboses, thrombophlebitis, degenerative diseases of the central nervous system, bronchial asthma (with difficulty of sputum discharge), elderly age.

    Pregnancy and lactation:

    Data on safety during pregnancy and during breastfeeding (breastfeeding) are not available.

    Dosing and Administration:

    Intravenous, intramuscular.

    For hypertensive crises, swelling of the lungs (brain), intravenously slowly (under the control of arterial pressure) 0.2-0.5 ml of the drug (in dilution of 20 ml of 0.9 % solution of sodium chloride or 5 % dextrose solution) or intramuscularly to 2 ml of the drug.

    For controlled hypotension - before the operation, intravenously drip, inject 40-60 mg (0.8-1.2 ml of the drug); if necessary, 120-180 mg (2.4-3.6 ml of the drug).

    In the treatment of "intermittent" lameness and other non-acute conditions, intramuscularly injected into the initial dose of 1 ml of the drug, if necessary, increase to 1.5-2 ml of the drug 2-3 times a day.

    The highest single dose for adults - 0.15 g (3 ml of the drug), daily - 0.45 g.

    Side effects:

    From the nervous system and sensory organs: weakness, dizziness, short-term memory impairment, paresis of accommodation, mydriasis, vascular injection of sclera.

    From the cardiovascular system and blood: orthostatic hypotension, tachycardia.

    On the part of the organs of the gastrointestinal tract: dry mouth, intestinal atony.

    From the genitourinary system: atony of the bladder.

    Overdose:

    Symptoms: lowering of blood pressure, violation of neuromuscular transmission, paralytic obstruction of the intestine, atonic anuria.

    Treatment: giving the patient a position with raised lower limbs; the introduction of anticholinesterase drugs,alpha-adrenomimetics (with severe hypotension), m-holinomimetikov, oxygen therapy, artificial ventilation.

    Interaction:

    The hypotensive effect is reduced when combined with tricyclic antidepressants, phenylephrine, ephedrine, is enhanced - with nondepolarizing muscle relaxants, other antihypertensive medications.

    Special instructions:

    To prevent the development of orthostatic hypotension after administration, patients should be in a horizontal position for 1-2 hours.

    Effect on the ability to drive transp. cf. and fur:

    During treatment, the management of vehicles is contraindicated, as well as engaging in activities that require the speed of psychomotor reactions and precise movements.

    Form release / dosage:Solution for intravenous and intramuscular injection 50 mg / ml.
    Packaging:
    • (1) - ampoules (10) / complete with a knife ampoule or scarifier and instructions for use / - cardboard boxes
    • (1) - ampoules (10) / set with a knife ampoule or scarifier and instructions for use / - 2 contour squeezed packs of 5 ampoules in a pack of cardboard
    • (2) - ampoules (10) / kit with a knife ampoule or scarifier and instructions for use / - 2 contour squeezed packs of 5 ampoules per pack of cardboard
    • (2) - ampoules (10) / set with a knife ampoule or scarifier and instructions for use / - cardboard boxes
    Storage conditions:

    In the dark place at a temperature of 15 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:5 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002131 / 01-2003
    Date of registration:15.01.2009
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp18.09.2015
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