Azamethonium bromide (Azamethonii bromidum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

N-holinoblokatory (ganglioblokatory)

Included in the formulation
  • Pentamine
    solution w / m in / in 
    DALHIMFARM, OJSC     Russia
  • Pentamine
    solution w / m in / in 
    NOVOSIBHIMFARM, OJSC     Russia
  • Pentamine
    solution w / m in / in 
    UZOLE-SIBERIAN CHEMICAL PLANT, OJSC     Russia
    • Pharmacodynamics:Bis-quaternary ammonium compound. Selectively blocks H-cholinergic receptors of vegetative ganglia. Pharmacological effects are caused by blockade of the ganglion blockers of vegetative innervation. Has ganglioblokiruyuschy and hypotensive effects, the duration of which is less than 3 hours.
    Pharmacokinetics:

    Absorption is low. Virtually does not penetrate the central nervous system. Elimination by the kidneys, mostly unchanged.

    Indications:

    - Hypertensive crisis.

    - Coping with acute attacks of bronchial asthma.

    - Eclampsia.

    - Swelling of the lungs or brain.

    - Spasm of peripheral vessels, obliterating the lesions of peripheral vessels (endarteritis, atherosclerosis, etc.).

    - Pain syndrome with ulcer of the stomach and duodenum, intestinal, bile, renal colic, causalgia.

    - Controlled arterial hypotension in anesthesiology.

    - Facilitating the passage of the cystoscope through the urethra in cystoscopy in men in urology.

    ICD-10
    Contraindications:
    • Closed-angle glaucoma.
    • Acute phase of myocardial infarction, severe arterial hypotension, shock.
    • Impaired liver and / or kidney function.
    • Pheochromocytoma.
    • Degenerative diseases of the central nervous system.
    • Individual intolerance.
    Carefully:

    The drug is used with caution with atony of the intestine and bladder of various etiologies, thromboses, thrombophlebitis, bronchial asthma and in elderly patients.

    Pregnancy and lactation:

    Data on the safety of the use of azamethonium bromide during pregnancy and during breastfeeding are absent.

    Dosing and Administration:

    Hypertensive crisis, relief of asthma attacks, eclampsia, pulmonary edema, cerebral edema - intravenously under the control of AD 0.2-0.5 ml of a 5% solution or in / m to 2 ml of a 5% solution.

    Spasm of peripheral vessels, obliterating peripheral vascular lesions (endarteritis, atherosclerosis, etc.), pain syndrome with ulcer of the stomach and duodenum, intestinal, biliary, renal colic, causalgia - intramuscularly in the initial dose of 1 ml of 5% solution, if necessary, increase the dose to 1,5-2 ml 2-3 times a day.

    Controlled arterial hypotension in anesthesiology - before the operation is administered iv drip in a dose of 40-60 mg (0.8-1.2 ml of a 5% solution). If necessary, increase the dose to 120-180 mg (2.4-3.6 ml of a 5% solution).

    The maximum single dose - 0.15 g (3 ml of 5% solution), daily - 0.45 g.

    Side effects:

    From the cardiovascular system: possible increased heart rate, Orthostatic hypotension (due to inhibition of the reflex mechanisms supporting constant blood pressure).

    From the digestive system: dry mouth; when used for a long time in elevated doses, intestinal atony is possible (up to paralytic intestinal obstruction).

    From the side of the central nervous system: general weakness, dizziness.

    From the side of the organ of vision: mydriasis, paresis of accommodation, injection of vessels of the sclera.

    From the urinary system: when used for a long time in elevated doses, atony of the bladder with anuria is possible.

    Overdose:No data.
    Interaction:

    Mutual potentiation of the effects observed in the combined use azametoniya bromide with antihypertensive, antihistamines, sedatives, hypnotics, antipsychotics, narcotic analgesics, tricyclic antidepressants, local anesthetics.

    When used concomitantly with anticholinergic agents, it may lead to a decreased effect on gastric secretion.

    With simultaneous application with insulin leads to an increase in sensitivity to insulin.

    Special instructions:

    Treatment ganglioblokatorami should be conducted under the close supervision of a doctor.

    To prevent the occurrence of orthostatic collapse during therapy, it is recommended 1-2 hours before the drug is administered in prone position.

    At the beginning of therapy it is recommended to check the patient's response to small doses of azamethonium bromide. To do this, 1/2 of the average dose is administered and the patient's condition is monitored. Important! With increased blood pressure, the hypotensive effect is more severe.

    Use of the drug in open-angle glaucoma can lead to a decrease in intraocular pressure as a result of the influence of ganglion blockers on the production of aqueous humor.

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