Lactitol (Lactitolum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Laxatives

Included in the formulation
  • Exportal®
    powder inwards 
    FPK FarmVILAR, ZAO     Russia
    • АТХ:

    A.06.A.D   Laxative preparations with osmotic properties

    A.06.A.D.12   Lactitol

    Pharmacodynamics:

    In the large intestine splits lactitol into low-molecular organic acids, which increases the osmotic pressure, increases the volume of fecal masses, softens them, normalizes the bowel, facilitates defecation.

    With hepatic encephalopathy due to a decrease in pH and an increase in osmotic pressure in the lumen of the intestine, there is a migration of ammonia from the blood to the large intestine, followed by the removal of nitrogen-containing toxic substances.

    Lactitol increases the number of acidophilic bacteria and suppresses proteolytic bacteria.

    Pharmacokinetics:

    After oral administration has a pharmacological effect in the large intestine, absorbed in 0,5-2%.

    Indications:

    Used to adjust the stool with constipation, with liver failure, and also in preparation for operations on the rectum.

    ICD-10

    IV.E70-E90.E72.2   Disorders of urea cycle exchange

    XI.K55-K63.K59.0   Constipation

    XI.K70-K77.K72   Hepatic failure, not elsewhere classified

    Contraindications:
    • Galactosemia.
    • Intestinal obstruction.
    • Suspicion of organic lesions of the gastrointestinal tract.
    • Rectal bleeding.
    • Individual intolerance.
    Carefully:

    Individual intolerance.

    Pregnancy and lactation:

    Recommendations for FDA - Category B. The drug has no systemic effect, is used for pregnant and lactating women.

    Dosing and Administration:

    When constipation is taken inwards while eating, mixing with drinks or liquid food, 20 grams once a day.

    With hepatic encephalopathy, hyperammonemia, the dose is selected individually: from 500 to 700 mg / kg for three doses.

    The highest daily dose: 60 g (6 sachets) - with hepatic encephalopathy.

    The highest single dose: 10 g per day.

    Use in children
    1-6 years: 2.5-5 g per day;
    6-12 years: 5-10 grams per day,
    12-16 years: 10-20 grams per day.
    Side effects:

    Digestive system: flatulence, a feeling of discomfort in the abdomen.

    Metabolism: violation of electrolyte balance during long-term treatment with high doses of hepatic encephalopathy.

    Allergic reactions.

    Overdose:

    Symptoms: nausea, vomiting.

    Treatment: decrease in the dose of the drug.

    Interaction:

    When used simultaneously with drugs that have a pH-dependent release, it must be taken into account that lactitol reduces the pH of the intestine.

    Special instructions:

    The drug has a low calorie content - 2 kcal / g and does not affect the blood glucose level, so it can be prescribed to patients with diabetes mellitus.

    During treatment, increased fluid intake is recommended.

    Instructions
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