Increased body weight; thromboembolism: reported cases of thromboembolism, including thrombophlebitis and pulmonary embolism; Nausea, vomiting, swelling and blood discharge from the uterine cavity, not associated with menstruation, are noted in approximately 1-2% of patients; the presence of dyspnea, pain, heart failure, arterial hypertension, hot flashes, mood changes, Cushingoid features on the face, temporary activation of tumor development (in the absence or presence of hypercalcemia), hyperglycemia, alopecia, carpal tunnel syndrome, diarrhea, lethargy, skin rashes.
It was reported on the development of pathological conditions associated with impaired functioning of the pituitary-adrenal system: glucose intolerance, the onset of diabetes mellitus and exacerbation of existing diabetes mellitus with a decrease in glucose tolerance and Cushing's syndrome.In rare cases, patients soon after the cessation of treatment with the drug observed clinical signs of adrenal insufficiency. It should be borne in mind the possibility of suppressing the function of the adrenal glands in all patients taking the drug for a long time, as well as after discontinuing the drug. In such cases, shock doses of glucocorticosteroids may be indicated as a substitution therapy.