Included in the formulation
АТХ:J.01.X.X.05 Methenamine
Pharmacodynamics:Uroantiseptic, prodrug, dissociation in acid medium to formaldehyde, denaturing bacteria proteins (nonspecific action). Has bactericidal and bacteriostatic effects. Sensitivity is universal. Particularly active in relation to E. coli, S. aureus, S. epidermidis. Bacteria that break down urea and alkalinize urine, prevent the dissociation of methenamine to formaldehyde (Proteus spp., Enterobacter aerogenes and etc.).
Pharmacokinetics:Absorption is good (destruction in the stomach by 30-60% if the drug is not in the enteric coating). There is practically no connection with plasma proteins. Biotransformation in urine (at pH 7.4 formaldehyde not formed; at a pH of 6-6%, at a pH of 5-20%). Half-life 4.3 hours. It is excreted by the kidneys (90% within 24 hours).
Indications:Urinary tract infections: cystitis, pyelitis.
XIV.N25-N29.N28.8 Other specified diseases of kidney and ureter
XIV.N30-N39.N30.9 Cystitis, unspecified
Contraindications:· Individual intolerance.
· Dehydration.
· Hepatic and / or renal insufficiency.
· Pregnancy and lactation.
· Children's age (up to 6 years).
Carefully:Atrioventricular blockade of I-III degrees.
Pregnancy and lactation:Recommendations FDA category C. The drug is not recommended during pregnancy and breastfeeding.
Dosing and Administration:Inside to 0.1-1 g 2 times a day. Intravenous for 2-4 g (5-10 ml of 40% solution).
Side effects:Digestive system: nausea, vomiting, diarrhea, abdominal pain.
Urine: albuminuria, hematuria, crystalluria.
Allergic reactions: skin rashes and itching.
Local reactions: hyperemia and soreness at the injection site.
Overdose:When an overdose is observed oppression of bone marrow hematopoiesis: leukopenia, agranulocytosis, infection. Treatment is symptomatic.
Interaction:Means, alkalizing urine (calcium and magnesium-containing, inhibitors, citrates, sodium hydrogen carbonate, thiazide diuretics), - decreased formation of formaldehyde in urine. Sulfanilamides - the risk of crystalluria.
Special instructions:When hematuria / proteinuria occurs, treatment is stopped.