Methylaminolevulinate (Methylii aminolevulinas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Other antineoplastic agents

Included in the formulation
  • Metvix®
    cream externally 
    Galderma S.A.     Switzerland
    • АТХ:

    L.01.X.D.03   Methylaminolevulinate

    Pharmacodynamics:

    With local use in the affected skin cells, proactive porphyrins accumulate - photoactive, fluorescing compounds. Under the influence of illumination, these porphyrins produce an active oxygen, which destroys the cell membranes and organelles, which leads to the death of pathological cells.

    Pharmacokinetics:No data.
    Indications:

    · Thin layered or unpigmented and not hyperkeratinized radial facial keratosis and scalp.

    · Surface and / or nodal basal cell carcinoma of the skin, not subject to treatment by other methods because of possible complications.

    · Intraepidermal squamous cell carcinoma of the skin, when surgical treatment is considered less expedient.

    ICD-10

    XII.L80-L99.L82   Seborrheic keratosis

    II.C43-C44   Melanoma and other malignant neoplasms of the skin

    Contraindications:

    · Individual intolerance.

    · Scleroderm-like basal cell carcinoma of the skin.

    · Porphyria.

    · Allergic reactions to peanut butter.

    · Children under 18 years of age.

    Carefully:No data.
    Pregnancy and lactation:The use of the drug is contraindicated in pregnancy and lactation.
    Dosing and Administration:

    Dosage is selected individually in each case.

    Side effects:

    Nervous system: paresthesia, headache.

    Skin: pain, burning sensation of the skin, formation of a scab, erythema.

    Allergic reactions.

    Overdose:No data.
    Interaction:Drug interactions are unknown.
    Special instructions:

    The intensity of light exposure to the surface of the affected area should not exceed 200 mW / cm2.

    Instructions
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