Included in the formulation
Pharmacodynamics:Acceptor or donor of protons of oxidation-reduction reactions. It is an antidote of cyanide, aniline, potassium permanganate. In high doses, poisoning with hydrocyanic acid converts hemoglobin to methemoglobin, which binds to cyanides to form a non-toxic cyanmethhemoglobin. In low doses, on the contrary, it restores methhemoglobin to hemoglobin.
It shows antiseptic activity due to interaction with proteins and mucopolysaccharides of microorganisms.
Pharmacokinetics:After oral administration, it is almost not absorbed in the gastrointestinal tract. After intravenous administration, it is evenly distributed in the body. The maximum concentration in the blood plasma is reached after 30 minutes. Metabolism in the liver before the formation of leukomethylene blue.
The half-life is 6-7 days. Elimination of the kidneys and gastrointestinal tract in the form of leukomethylene blue, which stains the urine in blue, which is used to diagnose kidney function.
Indications:Poisoning by carbon monoxide, methhemoglobin-forming poisons, hydrogen sulfide.It is used for the treatment of folliculitis, pyoderma, with infections of the urinary tract.
XIX.T90-T98.T95.9 Consequences of unspecified thermal and chemical burns and frostbites
XIX.T20-T32.T30.0 Thermal burn, unspecified degree of unspecified site
XIX.T51-T65.T58 Toxic effect of carbon monoxide
III.D70-D77.D74.9 Methemoglobinemia, unspecified
XII.L00-L08.L08.0 Pyoderma
Contraindications:Individual intolerance.
Carefully:Pregnancy, lactation - for intravenous administration.
Pregnancy and lactation:Recommendations for FDA - Category C. It is applied externally - it does not have a systemic effect. Intravenous use of the drug only for life indications.
Dosing and Administration:Application in children
Externally: 4-10 mg per year of life.
Adults
Intravenously slow: 50-100 mg of a 1% solution in a 25% solution of dextrose - for poisoning with cyanides, hydrogen sulphide, carbon monoxide.
Intravenously slow: 0.1-0.15 ml of 1% solution per kg of weight - with poisoning with nitrites, aniline and its derivatives.
Inside, 0.1g 3-4 times / day - with diseases of the genitourinary system.
Outer 1% alcohol solution - for burns, pyoderma, folliculitis.
The highest daily dose: 100 mg.
The highest single dose: 100 mg.
Side effects:Central and peripheral nervous system: headache, mental discomfort.
Digestive system: abdominal pain, nausea, decreased appetite.
Urinary system: pain in the bladder and kidneys.
Allergic reactions.
Interaction:Not described.
Special instructions:After ingestion, it is required to take the pill with a full glass of water. Intravenous administration of the drug should be done slowly, with interruptions for several minutes. Do not administer the drug subcutaneously and intramuscularly.