Mupirocin (Mupirocinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Other antibiotics

Included in the formulation
  • Bactroban®
    ointment externally 
    GlaxoSmithKline Trading, ZAO     Russia
  • Bactroban®
    ointment nazal. 
    GlaxoSmithKline Trading, ZAO     Russia
  • Bonderm
    ointment externally 
    Beluga, medicines and cosmetics.     Croatia
  • Supirocin®
    ointment externally 
    Glenmark Pharmaceuticals Co., Ltd.     India
    • АТХ:

    D.06.A.X.09   Mupirocin

    Pharmacodynamics:

    Inhibits the synthesis of bacterial proteins by reversible and specific binding to isoleucine-transfer-RNA-synthesis, which leads to bacteriostatic action. The drug is a broad-spectrum antibiotic, effective against Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis, Bordetella pertussis, Pasteurella multocida, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii.

    Pharmacokinetics:

    The level of systemic absorption from the mucous is low, metabolized before monic acid, excreted by the kidneys.

    Indications:

    - bacterial skin infections: impetigo, folliculitis, furunculosis (including furuncles of the external auditory canal and auricle), ecthima;

    - atTory bacterial infections: infected eczema, infected injuries (abrasions, insect bites), minor (hospital-free) wounds and burns;

    - prevention of infections in surgical incisions and minor wounds;

    - inflammatory diseases of the nasal cavity.

    ICD-10

    X.J00-J06.J00   Acute nasopharyngitis (runny nose)

    X.J30-J39.J31.0   Chronic rhinitis

    XII.L00-L08.L01   Impetigo

    XII.L00-L08.L02   Abscess of skin, boil and carbuncle

    XII.L00-L08.L03   Phlegmon

    XII.L00-L08.L08.0   Pyoderma

    XII.L00-L08.L08.8   Other specified local infections of skin and subcutaneous tissue

    XII.L00-L08.L08.9   Local infection of skin and subcutaneous tissue, unspecified

    XII.L20-L30.L30.3   Infectious dermatitis

    XIX.T08-T14.T14.0   Superficial injury of unspecified area of ​​the body

    XIX.T08-T14.T14.1   Open wound of unspecified area of ​​the body

    XIX.T20-T32.T30   Thermal and chemical burns, unspecified

    XIX.T79.T79.3   Post-traumatic wound infection, not elsewhere classified

    XX.W50-W64.W57   Bite or sting with a non-toxic insect or other non-venous arthropod

    XXI.Z20-Z29.Z29.2   Another type of preventive chemotherapy

    Contraindications:

    Hypersensitivity, children under 3 years.

    Carefully:

    Renal failure. It is necessary to strictly follow the doctor's prescription for the dosage and duration of the course of application of the drug.

    Pregnancy and lactation:

    Category FDA - B. Adequate controlled studies in humans are not conducted. There is no information on the penetration into breast milk. Do not use when pregnant and breast-feeding.Use of the drug is possible if the expected benefit exceeds the possible risk of complications.

    Dosing and Administration:

    Outwardly, locally, 3 times a day, the course - 10 days. With intranasal application - 2-3 times a day, the course of treatment - 5-7 days.

    Side effects:

    When topical application may occur itching, tingling, burning, dryness, pain, redness, rash, swelling, nausea, abdominal pain, dizziness, secondary wound infections, ulcerative stomatitis.

    With intranasal application - cough, respiratory distress, sore throat (pharyngitis), pain in the ears, headache, burning, tingling in the nose, rhinitis, rhinorrhea, taste changes, itchy skin.

    Overdose:

    Not described, treatment is symptomatic.

    Interaction:

    Avoid concomitant use with other medicines for external use, as this may reduce the antibacterial activity of mupirocin in the ointment.

    Special instructions:

    It is necessary to strictly observe the compliance of the used dosage form with indications for use.

    Polyethylene glycol, which is part of the ointment for skin application, can be adsorbed through damaged skin,and since it is excreted by the kidneys, it should be used with caution in the presence of severe renal failure. Nasal ointment can not be used in ophthalmology.

    Does not affect the ability to drive vehicles or other mechanisms.

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