Mupirocin - antibiotic produced by a microorganism Pseudomonas fluorescens. Mupirocin suppresses the synthesis of the bacterial cell protein through reversible binding to isoleucyl-transport RNA synthetase, which prevents the inclusion of isoleukin in the protein chains under construction. When used in minimal inhibitory concentrations mupirocin has bacteriostatic, and in higher concentrations - bactericidal action.
Due to a specific mechanism of action and a unique chemical structure, there is no cross-resistance with other antibiotics.
With the correct application of mupirocin, the risk of the emergence of resistant strains of microorganisms is small.
Spectrum of antibacterial activity in vitro:
Gram-positive aerobes:
Staphylococcus aureus (including strains resistant to methicillin and producing beta-lactamases),
Staphylococcus epidermidis,
Staphylococcus species,
Coagulase-negative Staphylococcus;
Gram-negative anaerobes:
Haemophilus influenzae,
Neisseria gonorrhoeae,
Neisseria meningitidis,
Branhamella catarrhalis,
Pasteurella multocida,
Proteus mirabilis,
Proteus vulgaris,
Enterobacter cloacae,
Enterobacter aerogenes,
Citrobacter freundii,
Bordetella pertussis;