Side effects most common in clinical trials (possibly related to the use of naproxen):
On the part of the intestine: 3-9% - heartburn, abdominal pain, nausea, constipation; > 1% - diarrhea, indigestion, stomatitis; <1% - flatulence, bleeding / perforation, gastrointestinal ulcers (gastroduodenal), vomiting, increased activity of hepatic transaminases.
From the nervous system and sensory organs: 3-9% - headache, drowsiness, dizziness, tinnitus, visual impairment, hearing impairment; > 1% - vertigo.
From the cardiovascular system and blood (hematopoiesis, hemostasis):> 1% - palpitation; <1% - anemia, increased bleeding time.
On the part of the respiratory system: 3-9% - dyspnea.
From the skin: 3-9% - ecchymosis.
From the genitourinary system: <1% - renal dysfunction.
Allergic reactions: 3-9% - itching, skin rashes, anaphylactoid reactions.
Other: 3-9% - edema; > 1% - increased sweating, purpura, thirst.
Side effects that occurred with a frequency of <1% for clinical trials and post-marketing studies (possibly related to the use of naproxen):
On the part of the intestine: colitis, hematemesis, jaundice, pancreatitis, melena.
From the genitourinary system: glomerular nephritis, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, renal failure, renal papillary necrosis.
From the cardiovascular system and blood (hematopoiesis, hemostasis): agranulocytosis, eosinophilia, granulocytopenia, leukopenia, thrombocytopenia.
From the nervous system and sensory organs: depression, unusual dreams, inability to concentrate, insomnia, malaise, myalgia, muscle weakness.
Side effects occurred with a frequency of <1% (causal connection with application of naproxen not established):
From the cardiovascular system and blood (hematopoiesis, hemostasis): aplastic anemia, hemolytic anemia.
From the nervous system and sensory organs: aseptic meningitis, cognitive dysfunction.
On the part of the digestive tract: non-peptic ulceration of the gastrointestinal tract, ulcerative stomatitis.
Allergic reactions: epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, urticaria; photosensitivity reactions similar to bullous porphyric epidermolysis.
Others: vasculitis, hyperglycemia, hypoglycemia, alopecia, photodermatitis.