Included in the formulation
АТХ:D.08.A.X.07 Sodium hypochlorite
Pharmacodynamics:Chlorination of cellular proteins and enzyme systems with nonionized hypochlorous acid [NaOCl + H2O ↔ HOCl + NaOH; hypochlorite ion (ClO-) can also be active] and the death of microorganisms. Pharmacological effects: active against most bacteria, certain fungi, yeast microorganisms, algae, viruses and protozoa - fast, powerful, short duration: bactericidal, fungicidal, antiprotozoal, antiviral, antiseptic, disinfectant.
Pharmacokinetics:Not studied.
Indications:Treatment of the skin, mucous membranes, wounds (including gynecological diseases).
XIX.T08-T14.T14.1 Open wound of unspecified area of the body
XIX.T08-T14.T14.0 Superficial injury of unspecified area of the body
Contraindications:Hypersensitivity. Hypocoagulation, hypoglycemia, parenchymal and other hemorrhages, pregnancy, albuminuria (for intravenous administration).
Carefully:Children under 18 years old, breast-feeding. Elderly age, renal and hepatic insufficiency. Edema, arterial hypertension
(the condition may worsen), anuria or oliguria (increased risk of excessive sodium retention).
Pregnancy and lactation:FDA recommendation category C.
Category of recommendations FDA not determined. Qualitative and well-controlled studies on humans and animals have not been conducted. There is no information on the penetration into breast milk.
Dosing and Administration:Outwardly. Used washing, baths, irrigation, as well as applying moist compresses or bandages. The procedures are repeated as necessary.
Side effects:Allergic reactions.
Overdose:Sodium hypochlorite in contact with the acid of gastric juice releases hypochlorous acid, which causes irritation and erosion of the mucous membranes with pain and nausea, edema of the pharynx and larynx, more rarely - perforation of the esophagus and stomach. Decrease in blood pressure, delirium, coma. Irritation of the respiratory tract, coughing, choking, swelling of the lungs.
Treatment: when administered orally - water, milk. There is no consensus on antacids. Sodium thiosulfate 1-2.5% solution can be used, although without much success. If sodium hypochlorite hit on the skin - plenty of water.
Interaction:Pharmaceutically incompatible with alkalis (forms a precipitate), with sulfates, chlorides, salicylates, benzoates (forms insoluble compounds).
Do not mix with solutions of strong acids and ammonium; as a result of the reaction, chlorine is released in the form of gas and sodium tosylchloride.
Special instructions:Avoid contact with eyes. Simultaneous or consistent use of other antiseptic agents or soaps should not be avoided without first thoroughly washing the area treated (due to possible antagonism or inactivation). The drug is not suitable for disinfection of surgical materials and instruments.