Sodium citrate - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Included in the formulation

АТХ:

B.05.C.B.02 Sodium citrate

Pharmacodynamics:Reduces coagulability of blood, increases alkaline reserves of blood, alkalinizes urine. It binds Ca2 + ions (IV plasma coagulation factor) and makes hemocoagulation impossible (in vitro). Increases the concentration of Na + ions in the blood plasma. The change in the reaction of urine from acid to alkaline leads to the disappearance of dysuric phenomena.

Pharmacokinetics:After absorption, it is metabolized to bicarbonate, excreted by urine and increasing its volume and acidity.

Indications:Preservation of blood. Cystitis. Prevention of urate calculus formation in hyperuricemia.

ICD-10

XIV.N30-N39.N30 Cystitis

XXI.Z100.Z100 * CLASS XXII Surgical Practice

Contraindications:Individual intolerance.

Aluminum intoxication (citrates can increase the absorption of aluminum and increase intoxication, especially in renal failure).

Heart failure or severe myocardial damage (possible sodium retention in the body).

With severe renal dysfunction (with azotemia or oliguria) and renal failure (at a glomerular filtration rate of less than 0.7 ml / kg), the risk of sodium retention in the body increases.

In cases of urinary tract infections (active, caused by organisms splitting uric acid, in patients with oxalate kidney stones), enzymatic cleavage of citrate is possible; increasing urine pH can stimulate the growth of bacteria.

Carefully:No data.

Pregnancy and lactation:The category of FDA recommendations is not defined. The drug is not recommended during pregnancy and breastfeeding.

Dosing and Administration:Cystitis (symptomatic treatment for easily flowing infections): inside 1 packet (previously dissolved in 1 glass of water) 3 times a day (up to 10 g per day) for 2 days.

Prophylaxis of formation of urate calculus of kidneys with hyperuricemia (in the initial period of treatment by uricosuric agents): inside in several receptions up to 10 g per day.

Side effects:The cardiovascular system: increase in blood pressure.

Digestive system: decreased appetite, nausea, vomiting, abdominal pain, laxative effect - increased intestinal peristalsis (infrequently).

Others: metabolic alkalosis - a change in mood and behavior, pain or twitching of the muscles, nervousness, bradypnoe,unpleasant taste in the mouth, unusual weakness or fatigue, hypernatremia - dizziness, frequent pulse, irritability, muscle twitching, cramps, swelling of the feet or lower extremities, weakness (very rarely).

Overdose:Not described.

Interaction:Amphetamines, ephedrine, pseudoephedrine, quinidine - it is possible to suppress the secretion of urine and prolong the action of these drugs when combined with citrates.

Antacids, especially those containing aluminum or sodium hydrogen carbonate - possible development of systemic alkalosis when combined with citrates; citrates also increase the absorption of aluminum, which can lead to the development of acute intoxication with aluminum, especially in patients with renal insufficiency.

Sodium-containing drugs - increased risk of hypernatremia, especially with concomitant renal pathology.

Sodium bicarbonate - it is possible to accelerate the formation of oxalate stones in patients with urate concretions of the kidneys; possibly also the development of hypernatremia.

Lithium preparations - citrates can increase the excretion of lithium by the kidneys and reduce its therapeutic effect.

Salicylates - citrates can increase kidney excretion and reduce the therapeutic effect of salicylates.

Laxatives - it is possible to enhance the laxative effect; It is possible to use such combinations in the preoperative preparation of the intestine.

Ciprofloxacin, norfloxacin, ofloxacin - Citrate can reduce the solubility of these drugs in the urine; it is necessary to monitor the signs of crystalluria and nephrotoxicity.

Special instructions:No data.

Instructions

Sodium citrate (Natrii citras)