Included in the formulation
АТХ:D.06.A.X Other antibiotics for external use
D.06.A.X.04 Neomycin
Pharmacodynamics:Antibiotic from the group of aminoglycosides. Effective depending on the dose: in a high concentration has a bactericidal effect, in low - bacteriostatic. Oppresses the synthesis of protein prokaryotes, affecting the ribosomes.
Active against Gram-positive bacteria Actinomyces spp., Bacillus antracis, Corynebacterium diphtheriae, Clostridium spp., Staphylococcus spp., Streptococcus spp., Listeria monocytogenes, Neisseria meningitidis; and Gram-negative microorganisms: Borrelia spp., Bordetella pertussis, Treponema pallidum, Escherichia coli, Enterobacter aerogenes, Shigella spp., Salmonella spp., Haemophilus influenzae, Proteus spp., Pasteurella multocida, Vibrio cholerae, Fusobacterium spp., Klebsiella pneumoniae, Leptospira spp.
Active with respect to Mycobacterium tuberculosis.
Pharmacokinetics:After oral administration, up to 3% is absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 4 hours. The connection with plasma proteins is 10%.
Therapeutic effect develops after the reception. Metabolism is not affected.
The elimination half-life is 2-4 hours. Elimination by the kidneys in unchanged form, not absorbed part (97%) is excreted with feces. It is output by hemodialysis up to 50% every 4-6 hours.
Indications:For oral administration for infectious and inflammatory diseases of the gastrointestinal tract caused by neomycin-sensitive bacteria.It is used for sanation of the gastrointestinal tract before surgical treatment.
For local and external use it is used to prevent infectious complications in eye surgery.
I.A00-A09.A04 Other bacterial intestinal infections
I.A00-A09.A09 Diarrhea and gastroenteritis of allegedly infectious origin
VII.H00-H06.H01.0 Blepharitis
VII.H10-H13.H10.2 Other acute conjunctivitis
VII.H10-H13.H10.4 Chronic conjunctivitis
VII.H10-H13.H10.5 Blepharoconjunctivitis
VII.H15-H22.H16 Keratite
Contraindications: Renal failure, neuritis of the auditory nerve, individual intolerance.
Carefully:For topical application during pregnancy and lactation.
Pregnancy and lactation:Recommendations for FDA - for intake inside the category D. Contraindicated for oral administration during pregnancy and lactation.
Dosing and Administration:It is used for treatment children at the age of 1 year.
For 1 g every hour for 4 hours, children over 12 years of age, 1 g every 4 hours for 2-3 days before surgery.
When bacterial skin infections are used in the form of ointments and solutions. The maximum daily dose should not exceed 25-50 g of 0.5% ointment and 5-10 g of 2% ointment.
Adults
Inside to 0.1-0.2 g for 5-7 days, for preoperative preparation for 1-2 days: every 4 h to 1 g.
The highest daily dose: 6 g.
The highest single dose: 0.2 g.
Side effects:Central and peripheral nervous system: neuromuscular blockade, respiratory arrest.
Digestive system: candidiasis, nausea, vomiting, malabsorption syndrome.
Sense organs: deafness.
Urinary system: toxic nephrosis.
Dermatological reactions: candidiasis; itching, burning with local application.
Allergic reactions.
Overdose:Symtomas: respiratory arrest.
Treatment: hemodialysis, oxygen therapy, anticholinesterase drugs, calcium salts.
Interaction:Simultaneous use with anesthetics, inhalation of halogenated hydrocarbons, blockers of neuromuscular transmission, massive transfusions of citrated blood increases the risk of blockade of neuromuscular transmission.
Simultaneous use with warfarin enhances the therapeutic effect.
When used simultaneously with other aminoglycosides, the risk of ototoxicity increases.
The risk of nephrotoxicity increases with simultaneous use with amphotericin B, aldesleukin, salicylates, acyclovir, bacitracin, carmistine, ifosfamide, preparations of gold and lithium, sulfonamides, cytostatics.
Special instructions:It is applied internally in the absence of the effect of other antibacterial agents.
Used for topical application in the form of ointments and cream.