Combined drug, has anti-migraine, antispasmodic and analgesic effect.
Ergotamine - ergot alkaloid; is a partial agonist of serotonin receptors, indiscriminately blocks 5-HT1A-1D receptors.
Extended cranial vessels (the result of the action of camilophin) are the target for the action of ergotamine. The drug has a direct stimulating effect on the smooth muscles of the cranial vessels, causing their constriction. The vasoconstrictor effect of ergotamine is due to binding to the serotonin 5-HT1 receptor, which leads to its activation. This improves microcirculation, narrowing the branches of the basilar artery, which, however, does not worsen blood circulation in the cerebral hemispheres. The extracellular edema of the brain also decreases. In addition, ergotamine reduces the excitability of serotonergic neurons in the brain stem structures, thereby increasing the threshold of pain sensitivity. It has been established that ergotamine has peripheral adrenoblocking ability, which increases its sympatholytic properties.It should be noted that ergotamine is particularly effective at the beginning of the vasodilator phase of migraine.
Thus, against the background of the action of ergotamine, a tonic effect on the peripheral and cerebral vessels predominates, which is of therapeutic importance in the management of migraine attacks.
Propyphenazone - NSAIDs, blocks cycloo-oxygenase, as a result, the formation of prostaglandins with a pro-inflammatory effect is disrupted: PGE2, PGF2, has an analgesic, anti-inflammatory effect. In addition, it should be noted the effect of propifenazone on thalamic centers of pain sensitivity, which leads to blocking of pain impulses to the cerebral cortex.
Caffeine inhibits phosphodiesterase than prevents the destruction of CAMP to an inactive metabolite AMP, resulting in increased concentration of cAMP in the tissues of the brain, heart and other organs. The second mechanism of action of the drug is associated with blockade of adenosine receptors. Adenosine, stimulating the corresponding adenosine receptors, causes hyperpolarization of myocardial and CNS cells. This effect is of a protective nature, since adenosine accumulates during hypoxia, and caffeine blocks adenosine receptors and eliminates the inhibition process associated with the action of adenosine.
Caffeine causes stimulation of the central nervous system, mainly the cortex of the brain, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, a sense of fatigue. Has a pronounced cardiotonic action: increases the strength and heart rate, increases blood pressure with hypotension. Caffeine accelerates the absorption of ergotamine and enhances its therapeutic effect. Also caffeine has a tonic effect on the cerebral vessels.
Camilofin has an antispasmodic effect, eliminating the initial vasospasm in the prodromal phase of a migraine attack.
Mecloxamine is a blocker of histamine receptors and also has a mild sedative and antiemetic effect. It affects the metabolism of serotonin and histamine, suppressing the secretion of these compounds in the brain tissue, which prevents an increase in the permeability of blood vessels.
Has anticholinergic, antihistamine, moderately sedative and antiemetic effect.