Riboflavin - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Vitamins and vitamin-like remedies

Included in the formulation

Riboflavin mononucleotide

solution w / m

PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia

АТХ:

A.11.H.A Other vitamins

A.11.H.A.04 Riboflavin (vitamin B2)

Pharmacodynamics:

Coenzyme of two flavoprotein enzymes (FAD and flavin mononucleotide) required for tissue respiration (transfer of H⁺).

Pharmacokinetics:

Absorption is rapid (in the duodenum). Relationship with plasma proteins 60%. Biotransformation in the liver. Half-life66-84 min. Elimination of the kidneys in the form of metabolites, in high doses - in unchanged form.

Indications:

Hypo-and beriberi B2, hemorrhagia, conjunctivitis, keratitis, iritis, corneal ulcer, cataract, long-lasting non-healing wounds and ulcers, general eating disorders, radiation sickness, asthenia, bowel disorders, hepatitis.

ICD-10

IV.E50-E64.E53 Insufficiency of other B vitamins

V.F40-F48.F48.0 Neurasthenia

VII.H10-H13.H10.2 Other acute conjunctivitis

VII.H10-H13.H10.4 Chronic conjunctivitis

VII.H15-H22.H16 Keratite

VII.H15-H22.H16.0 Corneal ulcer

VII.H15-H22.H20.0 Acute and subacute iridocyclitis

VII.H15-H22.H20.1 Chronic iridocyclitis

VII.H25-H28.H25 Star cataract

VII.H25-H28.H26 Other cataracts

XI.K70-K77.K73.8 Other chronic hepatitis, not elsewhere classified

Contraindications:

Hypersensitivity to riboflavin, nephrolithiasis.

Pregnancy and lactation:

Complications when taking in the recommended doses are not registered. Penetrates into breast milk.Complications in humans when taken in recommended daily doses are not registered. Compatible with breastfeeding. To cover the needs of a healthy, well-nourished lactating mother, riboflavin is usually not required.

Category of recommendations FDA is not defined.

Dosing and Administration:Single dose - 5-10 mg, for children - 2-5 mg 1-3 times / day for 1-1.5 months.

Side effects:

Possible: allergic reactions, impaired renal function, impaired vision.

Overdose:

Not described.

Interaction:

Alcohol - delayed absorption of riboflavin.

Amitriptyline, imipramine, chlorpromazine - block flavinokinase, disrupt the conversion of riboflavin into an active form (coenzyme), reduce effectiveness.

Doxycycline, lincomycin, oxytetracycline, tetracycline, erythromycin - decrease in the effect of antibacterial drugs.

M-holinoblokatory - increased absorption and bioavailability of riboflavin.

Probenecid - Reduction of absorption of riboflavin in the intestine.

Thyroid hormones - acceleration of riboflavin metabolism.

Chloramphenicol - riboflavin reduces and prevents its side effects (violation of hemopoiesis, optic neuritis).

Special instructions:

In admission in large doses causes reversible staining of urine in an intensely yellow or orange color.

Sources of riboflavin: milk and dairy products, fish, meat, green vegetables, whole grains and fortified cereals, bread. When cooking, the vitamin B2 content in foods decreases. Do not use vitamin B2 as a substitute for a balanced diet!

Daily requirement: adults - 2.5 mg, with severe physical exertion - 3 mg; children aged 6 months to 1 year - 0.6 mg, 1-1.5 years - 1.1 mg, 1.5-2 years - 1.2 mg, 3-4 years - 1.4 mg, 5- 6 years - 1.6 mg, 7-10 years - 1.9 mg, 11-13 years - 2.3 mg; young men aged 14-17 years - 2.5 mg; girls aged 14-17 years - 2.2 mg. The recommended daily requirement for riboflavin is different in different countries.

Effective for the prevention of migraine: 400 mg / day (treatment 3 months) or 25 mg / day.

According to some studies, eating fresh fruits and vegetables reduces the risk of developing gastrointestinal cancer.

Instructions

Riboflavin (Riboflavinum)

Hypo-and beriberi B2, hemorrhagia, conjunctivitis, keratitis, iritis, corneal ulcer, cataract, long-lasting non-healing wounds and ulcers, general eating disorders, radiation sickness, asthenia, bowel disorders, hepatitis.