Active substanceRiboflavinRiboflavin Similar drugsTo uncover Riboflavin mononucleotide solution w / m PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia Dosage form: & nbspSolution for intramuscular injection. Composition:Riboflavin sodium phosphate - 10.0 mg;Excipients: Chlorobutanol hemihydrate (Chlorobutanol hydrate) - 0.5 mg; Disodium edetate (disodium ethylenediaminetetraacetic acid, Trilon B) 0.3 mg; Water for injection - up to 1 ml. Description:Transparent or slightly opalescent liquid of yellow-orange color. Pharmacotherapeutic group:Vitamin. ATX: & nbspA.11.H.A Other vitaminsA.11.H.A.04 Riboflavin (vitamin B2) Pharmacodynamics:Vitamin B2 has a metabolic effect; interacts with ATP, forming coenzymes of flavinproteins - flavinadenine mononucleotide and flavinadenine dinucleotide, which are components of enzymes such as succinate dehydrogenase, cytochrome reductase, diaphorase, oxidases of amino acids, etc. Regulating the redox processes, takes part in the transfer of hydrogen (H +), tissue respiration, carbohydrate, protein and fat metabolism, in maintaining the normal visual function of the eye, the synthesis of hemoglobin and erythropoietin.The activated by riboflavin pyridoxal kinase converts pyridoxine (vitamin B6) into the active form pyridoxalphosphate.Promotes the conversion of tryptophan into niacin, preserving the integrity of red blood cells. It is part of the glutathione reductase, xanthine oxidase.It is synthesized by normal intestinal microflora and is itself necessary for its maintenance. Pharmacokinetics:Quickly absorbed from the injection site. Communication (mainly in the form of metabolites - flavinadenine mononucleotide and flavinadenine dinucleotide) with plasma proteins - 60%. Distributed byall organs and tissues, is deposited in muscle tissue, liver, spleen, kidneys and myocardium. Penetrates through the placenta and into breast milk.Metabolised in the liver. The half-life (T 1/2) is 66-84 min.It is excreted from the body by the kidneys, almost completely in the form of metabolites, when taken in high doses - mostly unchanged. In small quantities is excreted through the intestine. It is excreted in hemodialysis, but much slower than in renal excretion. Indications:Riboflavin - mononucleotide is used as directed by a doctor.Assign adults and children with hypo- and avitaminosis B2, as well as in the complex therapy of skin diseases (with itching dermatoses, neurodermatites, chronic eczema, photodermatoses, etc.) Contraindications:Hypersensitivity to the drug. Dosing and Administration:Intramuscularly. Adults appoint 10 mg (1 ml of 1% solution) once a day.The course of treatment is 10-20 days.Children, depending on the age, prescribe 5 mg-10 mg (0.5-1 ml of 1% solution) for 3-5 consecutive days, then 2-3 times a week. Side effects:In rare cases, allergic reactions are possible. Interaction:Reduces the activity of doxycycline, tetracycline, oxytetracycline, erythromycin and lincomycin. Incompatible with streptomycin.Chlorpromazine, imipramine, amitriptyline due to blockade of flavinokinase, the incorporation of riboflavin into flavinadenine mononucleotide and flavinadenine dinucleotide is disrupted and its excretion in the urine is increased.Thyroid hormones accelerate metabolism.Reduces and prevents side effects of chloramphenicol (violation of hemopoiesis, optic neuritis).Compatible with drugs that stimulate hemopoiesis, antihypoxants, anabolic steroids. Special instructions:It should be borne in mind that riboflavin is destroyed under the influence of the rays of the blue part of the solar spectrum (of the order of 450 nm). Stains urine in a light yellow color.Injections are somewhat painful. Form release / dosage:Solution for intramuscular injection 10 mg / ml. Packaging:1 ml per ampoule of colorless glass 1 hydrolytic class.5 or 10 ampoules are placed in a contour mesh package.1 or 2 contour squares are placed in a pack of cardboard.In each pack you put the instruction for medical use. Storage conditions:In the dark place at a temperature of no higher than 25 0C. Keep out of the reach of children. Shelf life:2 years. Do not use after the expiration date indicated on the package. Terms of leave from pharmacies:On prescription Registration number:LSR-002944/07 Date of registration:01.10.2007 The owner of the registration certificate:PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia Manufacturer: & nbspFARMSTANDART-UFAVITA, JSC Russia Information update date: & nbsp15.09.2015 Illustrated instructions × Illustrated instructions Instructions