Superoxide dismutase (Superoxidedismutase)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antihypoxants and antioxidants

Included in the formulation
  • Reksod®
    lyophilizate in / in 
    GosNII OCHB FMBA, FSUE     Russia
  • Reksod®
    solution in / in 
    GosNII OCHB FMBA, FSUE     Russia
  • Рексод®-ОФ
    lyophilizate d / eye 
    GosNII OCHB FMBA, FSUE     Russia
    • АТХ:

    S.01.X   Other drugs for the treatment of eye diseases

    Pharmacodynamics:

    Catalysis of the reaction of the dismutation (reduction) of the superoxide ion (O2-) at oxygen and hydrogen peroxide.

    Pharmacokinetics:

    Half-life 4-6 hours Cmax 24-837 mg / l. Elimination by the kidneys.

    Indications:

    - primary open-angle glaucoma;

    - Adenoviral lesion of the eyes;

    secondary keratopathy.

    ICD-10

    I.B25-B34.B30.0   Keratoconjunctivitis caused by adenovirus (H19.2 *)

    VII.H15-H22.H16   Keratite

    VII.H40-H42.H40.1   Primary open angle glaucoma

    Contraindications:

    - age up to 18 years;

    - Pregnancy;

    lactation period (breastfeeding).

    Pregnancy and lactation:

    The category of the FDA recommendation is not defined.

    Qualitative controlled studies in animals and humans were not conducted. Do not apply! There is no information on the penetration into breast milk. Do not apply!

    Dosing and Administration:

    Buried in the conjunctival sac. To prepare eye drops, the contents of the 0.8 million ED bottle are dissolved in 2 ml of water for injection. The resulting solution (eye drops) is stored in the refrigerator at a temperature of 4 ° to 10 ° C for not more than 3 days.

    In the case of primary open-angle glaucoma, 2 drops are injected into the eye every 5 minutes for 30 minutes 2 times / day (morning and evening). The course of treatment is not less than 10 days. The course of treatment can be repeated after 1-3 months. Repeat the course of treatment is necessary at a developed and far-reaching stage of the disease.

    With secondary keratopathies: 2 drops 5-8 times / day; course - 3-7 days.

    With adenovirus eye lesions: 2 drops 6-8 times / day with an interval of 1-2 hours; course of treatment - at least 10 days.

    Local application of other ophthalmic drugs is possible not earlier than 10 min after instillation of the drug.

    Side effects:

    Local reactions: there may be a feeling of dry eyes, redness, foreign body sensation that passes after the course of treatment; in some cases - allergic reactions.

    Overdose:

    Not described.

    Interaction:

    Other means for topical application in ophthalmology - apply 10 minutes after using superoxide dismutase.

    Special instructions:

    Efficacy in the prevention of chronic lung disease in premature infants is not proven.

    In the world practice, as an agent for the treatment of diseases and injuries, the eye is not used.

    Instructions
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