Tropicamide - instructions for use, dose, side effects, contraindications

It blocks m-holinoretseptory circular muscle of the iris and ciliary muscle, causing paralysis of accommodation and mydriasis. After 7-10 minutes after instillation, the pupil dilates. Completely the effect passes through 6 hours.

Pharmacokinetics:

After instillation of the drug into the conjunctival sac tropicamide to a small extent is subjected to systemic absorption (especially in children and the elderly).

Indications:

For diagnostic purposes, if necessary, mydriasis and cycloplegia, including in the study of the fundus and the definition of refraction. Hypersensitivity to other drugs that dilate the pupil (atropinescopolamine).In the complex therapy of inflammatory processes and synechia.

ICD-10

XXI.Z00-Z13.Z01.0 Examination of eyes and eyesight

Contraindications:

Hypersensitivity, glaucoma (especially closed-angle), increased intraocular pressure.

Carefully:

Increased sensitivity to tropicamide and other such drug substances was detected in infants, small children, blond and blue-eyed children, in adults and children with Down's syndrome in children and adults with brain impairment and spastic paralysis. Pregnancy, breast-feeding, breast age.

Pregnancy and lactation:Adequate and well-controlled studies in humans and animals have not been conducted. There is no information on the penetration into breast milk.

Recommendations for FDA - Category C.

Dosing and Administration:

Investigation of the fundus (fundoscopy) - 1 drop of 0.5% solution 2 times with an interval of 5 minutes, or 3 times for 10 minutes.

Determination of refraction by the method of skiascopy - 1 drop of 1% solution 4-6 times in 5-10 minutes, the spasm of accommodation occurs in 1 hour.

Inflammatory processes and adhesions in the chambers of the eye - 1-2 drops to 6 times a day.

Side effects:

Local reactions: increased intraocular pressure, acute attack of closed angle glaucoma, blurred vision, photophobia, irritation (swelling, hyperemia).

System Effects: behavioral disorders or psychotic reactions (unusual behavior, especially in children), clumsiness and instability, headache, confusion, palpitations, reddening of the face, visual and auditory hallucinations, thirst, dry mouth, dry skin, fever, skin rashes, slurred speech, cramps, bloating, delayed urination, unusual drowsiness, fatigue, weakness.

Overdose:

Symptoms: increased side effects.

Treatment: intravenous injection of physostigmine (children - 0.5 mg, in the absence of the effect of increasing the dose to 2 mg, adults - 2 mg, in the absence of the effect of repeated intravenous injection of 1-2 mg after 20 minutes).

Interaction:

Sympathomimetics - strengthening of mydriatic action.

Tricyclic antidepressants, phenothiazines, antihistamines - strengthening of systemic cholinoblocking action.

Special instructions:

In comparison with other mydriaticians tropicamide causes a minimum of side effects when used in healthy newborns, and in combination with cyclopentolate and phenylephrine is the most effective mydriatic.

Combination tropicamide 0,5 % + phenylephrine 2.5% provides maximum mydriasis and causes a minimum of side effects.

Instructions

Tropicamide (Tropicamidum)