Included in the formulation
АТХ:C.07.C.B Selective beta-1 blockers in combination with other diuretics
Pharmacodynamics:Combined long-acting drug. It consists of active substances supplementing each other's action.
Atenolol
Selective beta1-blocker, which does not have internal sympathomimetic activity. Reduces the heart rate, reduces the shock and minute blood volume within 24 hours.
Chlorthalidone
A neyiasidny diuretic of moderate action, stimulates the excretion of sodium, chlorine, potassium, magnesium and water ions, delays calcium ions in the body. By reducing the sodium content in the vascular wall, it decreases sensitivity to vasoconstrictive effects. Duration of action: from 24 to 48 hours.
Pharmacokinetics:After oral intake absorbed in the gastrointestinal tract in 50%.
The half-life of atenolol is 6-9 hours. The maximum concentration is achieved in 2-4 hours. Atenolol binds to plasma proteins up to 16%, chlorthalidone - up to 90%, including with erythrocytes. Metabolised in the liver, atenolol is eliminated by the kidneys, chlorthalidone is excreted through the intestine and with urine.
Indications:It is used for the treatment of hypertensive disease, with secondary hypertensive states.
IX.I10-I15.I10 Essential [primary] hypertension
IX.I10-I15.I15 Secondary Hypertension
Contraindications:Cardiogenic shock, atrioventricular block II-III degree, bradycardia, chronic heart failure - resistant to the action of cardiac glycosides, bronchial asthma, renal and hepatic insufficiency.
Individual intolerance.
Carefully:Chronic bronchitis with asthmatic component, obliterating arterial diseases, atrioventricular block I degree, disturbance of water-electrolyte balance.
Pregnancy and lactation:Recommendations for Food and Drug Administration (US Food and Drug Administration) - category D without teratogenicity. Not applicable in pregnancy and lactation.
Dosing and Administration:It is taken orally 1 tablet once a day (in the morning).
The highest daily dose: 2 tablets.
The highest single dose: 1 tablet.
Side effects:Central nervous system: dizziness, insomnia, asthenia.
Respiratory system: dyspnea, rarely - bronchospasm.
Cardiovascular system: bradycardia, atrioventricular block, cold extremities.
System of blood: neutropenia, thrombocytopenia.
Sense organs: "dry eye syndrome", transient visual impairment.
Gastrointestinal tract: indigestion, diarrhea or constipation.
Reproductive system: decreased potency.
Skin: Hyperhidrosis.
Allergic reactions.
Overdose:Pronounced bradycardia, arterial hypotension.
Treatment. Intravenous 1-2 mg atropine, 2.5 mcg / kg dobutamine, intravenously bolus 10 mg glucagon, intravenously drip 10-20 mcg isoprenaline at a rate of not more than 5 mcg per minute.
Interaction:Strengthens the effect of lidocaine in systemic application.
Negative dromo-, foreign, chromotropic influences are intensified with simultaneous admission with amiodarone, anesthetics, antiarrhythmics, digoxin, diltiazem, verapamil.
Increases the bioavailability of atenolol together with cimetidine.
Special instructions:With prolonged treatment, it is necessary to prescribe potassium preparations.
When giving general anesthesia to patients receiving atenolol, means with minimal inotropic action are used. Before surgery, it is recommended to stop taking the medication 48 hours before the operation.