Tenoretic ® is usually well tolerated.
When using Tenoretic® or any of its components with a frequency of development often (> 1/100), infrequently (> 1/1000, <1/100), rarely (> 1/10000, <1/1000), very rarely <1/10000) and unspecified frequency, the following side effects were reported:
Laboratory indicators:
Often - associated with chlorthalidone hyperuricemia, hyponatremia, hypokalemia, violation of glucose tolerance (see section "Special instructions").
Infrequently, an increase in the activity of "hepatic" transaminases.
Very rarely - an increase in the titer of antinuclear antibodies, although the clinical significance of this fact is not clear.
From the cardiovascular system:
Often - bradycardia, manifestations of angiospasm (cooling of the lower limbs)
Rarely, the development (aggravation) of symptoms of heart failure, the triggering of cardiac blockade, orthostatic hypotension, which can be accompanied by syncope, the manifestation of the symptom of "intermittent" lameness, in the susceptible patients may appear Raynaud's syndrome.
From the side of the blood and lymphatic system:
Rarely - purpura, thrombocytopenia, leukopenia (associated with chlorthalidone).
From the central nervous system:
Infrequent sleep is infrequent.
Rarely - confusion, dizziness, headache, paresthesia, mood lability, "nightmarish" dreams, psychosis and hallucinations.
From the digestive system:
Often - gastrointestinal disorders, nausea (associated with chlorthalidone).
Rarely, dryness of the oral mucosa.
Unspecified frequency - constipation.
From the liver and bile excretory system:
Rarely, hepatotoxicity with intrahepatic cholestasis, pancreatitis (associated with chlorthalidone).
From the skin:
Rarely - alopecia, psoriasis-like skin reactions, exacerbation of psoriasis, skin rash.
Unspecified frequency - reactions of hypersensitivity, including angioedema and urticaria.
From the respiratory system:
Rarely is the occurrence of bronchospasm in patients with bronchial asthma, including those who have an indication of bronchospasm in the anamnesis.
From the sense organs:
Rarely - dry eyes, visual impairment.
On the part of the reproductive system:
Rarely, impotence.
Are common:
Often - increased fatigue.
In the event that any of the above reactions may adversely affect a patient's health, consideration should be given to the withdrawal of the drug.
In the postmarketing application, the following adverse events were also reported: Increase in activity of "liver" enzymes and / or content bilirubin, Peyronie's disease, sick sinus syndrome, lupus syndrome (as well as the use of other beta-blockers), anorexia, gastric irritation, vomiting, convulsions, jaundice (intrahepatic cholestatic jaundice), vertigo, xanthopsia, agranulocytosis, aplastic anemia, photosensitivity, necrotizing vasculitis (vasculitis, cutaneous vasculitis), Lyell syndrome (toxic epidermal necrolysis), hyperglycemia, glycosuria, cramping, weakness, anxiety.