From the side cardiovascular system and blood (hematopoiesis, hemostasis): arterial hypertension, peripheral edema, left ventricular hypertrophy of the heart, circulatory insufficiency, arrhythmia, bradycardia (up to cardiac arrest), ECG changes characteristic of hypokalemia; hypercoagulation, thrombosis, obliterating endarteritis; in patients with acute and subacute myocardial infarction - the spread of the focus of necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle.
From the side organs of the digestive tract: steroid ulcer with possible perforation and bleeding,pancreatitis, flatulence, ulcerative esophagitis, indigestion, nausea, increased or decreased appetite, vomiting, hiccough; in rare cases - increased activity of hepatic transaminases and alkaline phosphatase.
From the side skin integument: atrophic bands, acne, delayed wound healing, thinning of the skin, petechiae and hematomas, erythema, excessive sweating, ecchymosis, hyper- or hypopigmentation, propensity to develop pyoderma and candidiasis.
From the side nervous system and sense organs: increase in intracranial pressure with the syndrome of the congestive nipple of the optic nerve (pseudotumor of the brain - most often in children, usually after too rapid reduction of the dose, symptoms - headache, reduced visual acuity or double vision), convulsions, dizziness, headache, sleep disturbance, mental disorders (most often appear within the first 2 weeks of treatment, symptoms can mimic schizophrenia, mania or delirious syndrome; women are most susceptible), posterior subcapsular cataract (usually occurs after discontinuing Nia treatment but may require surgical treatment), increased intraocular pressure,glaucoma (usually after treatment for at least a year), exophthalmos, a tendency to develop secondary bacterial, fungal or viral eye infections, trophic corneal changes.
From the side endocrine system: secondary adrenal and hypothalamic-pituitary insufficiency (especially in stressful situations such as illness, trauma, surgery), Itenko-Cushing's syndrome, growth inhibition in children, menstrual irregularities, decreased glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus , hirsutism.
From the side metabolism: hypocalcemia, negative nitrogen balance due to protein catabolism, hyperglycemia, glucosuria, increased excretion of Ca2 +; caused by mineralocorticoid activity - hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).
From the side musculoskeletal system: muscle weakness, steroid myopathy (more often in women), loss of muscle mass, rupture of tendons, osteoporosis, compression fracture of the spine, aseptic necrosis of femoral and humerus head, pathological fractures of long tubular bones.
Allergic reactions: Allergic dermatitis, urticaria, anaphylactic reactions, angioedema.
Other: weight gain, masking of symptoms of infectious diseases, syncope, development or exacerbation of infections (this side effect is promoted by jointly used immunosuppressants and vaccination), leukocyturia, withdrawal syndrome.