Aceclofenac (Aceclophenacum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

NSAIDs - Derivatives of acetic acid and related compounds

NSAIDs - Fenamates

Included in the formulation
  • Alental®
    pills inwards 
    VERTEKS, AO     Russia
  • Asinak
    pills inwards 
    Medley Pharmaceuticals, Ltd.     India
  • Atsklagin®
    pills inwards 
    Teva Pharmaceutical Enterprises Co., Ltd.     Israel
  • Aceclofenac
    pills inwards 
    VELFARM, LLC     Republic of San Marino
  • Aertal®
    powder inwards 
    Almiral S.A.     Spain
  • Aertal®
    cream externally 
    Almiral S.A.     Spain
  • Aertal®
    pills inwards 
    Almiral S.A.     Spain
    • АТХ:

    M.01.A.B   Derivatives of acetic acid

    M.01.A.B.16   Aceclofenac

    Pharmacodynamics:

    Not selectively inhibits COX-1 and COX-2, regulating the synthesis of prostaglandins. Has analgesic, antipyretic and anti-inflammatory effect. Reduces thrombosis, aggregation and adhesion of platelets, suppressing the synthesis of thromboxane A2 in thrombocytes.

    Pharmacokinetics:

    It binds to blood plasma proteins in 99%. Maximum concentration in the blood after 1.5-3 hours after administration. It penetrates into the synovial fluid, where up to 57% of the volume of the drug is concentrated in the plasma.

    Half-Elimination (half-life) of the drug is 4 hours. Metabolism in the liver by hydroxylation, elimination by the kidneys.

    Indications:It is used for the treatment of inflammatory diseases of the musculoskeletal system, with rheumatoid arthritis, gouty arthritis, osteoarthritis.
    ICD-10

    XIII.M05-M14.M05   Seropositive rheumatoid arthritis

    XIII.M05-M14.M07 *   Psoriatic and enteropathic arthropathies

    XIII.M05-M14.M08   Juvenile [juvenile] arthritis

    XIII.M05-M14.M10   Gout

    XIII.M15-M19.M15   Polyarthrosis

    XIII.M45-M49.M45   Ankylosing spondylitis

    Contraindications:

    Peptic ulcer of stomach and duodenum, violation of blood coagulation and hematopoiesis, hyperkalemia.

    Individual intolerance to non-steroidal anti-inflammatory drugs and aspirin.

    Carefully:

    Chronic heart failure, active inflammatory processes of the liver, chronic renal failure, the use of diuretics.

    Pregnancy and lactation:Recommendations for FDA - category C. The use during pregnancy is contraindicated in III trimester. AT I and II trimesters, and also during lactation aceclofenac is prescribed in situations where the risk from taking the drug is lower than the expected efficacy.
    Dosing and Administration:

    Inside 100 mg twice a day.

    The highest daily dose: 200 mg.

    The highest single dose: 100 mg.

    Side effects:

    Central and peripheral nervous system: dizziness, agitation, headache, depression, cognitive disorders, sleep disorders, tremor, paresthesia, aseptic meningitis.

    The cardiovascular system: arterial hypertension, tachycardia.

    The system of hematopoiesis: leukopenia, thrombocythemia, agranulocytosis, aplastic anemia.

    Digestive system: gastralgia, dyspeptic disorders, anorexia, melena, constipation.

    Urinary system: peripheral edema, proteinuria.

    Allergic reactions.

    Overdose:

    Increased side effects, hyperventilation of the lungs, convulsive alertness.

    Treatment is symptomatic.
    Interaction:

    Increases the concentration in the plasma digoxin, phenylthionine, lithium preparations.

    Reduces the effectiveness of diuretics and antihypertensive drugs.

    Increases the toxicity of methotrexate - recommended interval between taking drugs in 24 hours.

    The concentration of the drug in the blood plasma decreases with simultaneous use with acetylsalicylic acid.

    Changes the effect of oral hypoglycemic drugs: hypo- or hyperglycemia.

    Special instructions:

    With long-term use - monitoring of liver function, peripheral blood, testing of feces for occult blood.

    Instructions
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