Ceftibuten (Ceftibutenum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Cephalosporins

Included in the formulation
  • Cedex®
    capsules inwards 
    MSD FARMASYUTIKALS, LLC     Russia
  • Cedex®
    powdersuspension inwards 
    MSD FARMASYUTIKALS, LLC     Russia
    • АТХ:

    J.01.D.D.14   Ceftibuten

    Pharmacodynamics:

    Third-generation cephalosporin antibiotic.

    Has bactericidal action due to inhibition of bacterial cell wall synthesis. Violates the synthesis of the biopolymer peptidoglikana - the main component of the cell wall of bacteria. It inhibits the peptidoglycan transpeptidase, inhibits the activity of the endogenous inhibitor, which leads to activation of murein hydrolase, which cleaves peptidoglycan. Effective against fissile bacteria, in the walls of which the synthesis of peptidoglycan occurs.

    It is active against most Gram-positive and Gram-negative bacteria, including Edwardsiella tarda, Citrobacter freundii, Streptococcus spp., Morganella morganii, Serratia spp., Hafnia alvei, Yersinia enterocolitica.

    Inactive for Acinetobacter spp., Enterococcus spp., Staphylococcus spp., Listeria spp., Flavobacterium spp., Pseudomonas spp.

    It is resistant to the action of β-lactamases: penicillinase, cephalosporinase.

    Pharmacokinetics:

    After oral administration, up to 90% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved in 2-3 hours. The connection with plasma proteins is 62-64%.

    Not exposed to metabolism. Does not penetrate the blood-brain barrier.

    Half-life is 2.5 hours. Elimination by the kidneys.

    Indications:

    It is used for the treatment of infections caused by microorganisms sensitive to the preparation: upper and lower respiratory tract and ENT organs - pharyngitis, bronchitis, pneumonia, tonsillitis, scarlet fever, acute sinusitis, otitis media in children; complicated and uncomplicated urinary tract infections, gastritis and enteritis in children.

    ICD-10

    I.A00-A09.A09   Diarrhea and gastroenteritis of allegedly infectious origin

    X.J00-J06.J00   Acute nasopharyngitis (runny nose)

    X.J30-J39.J31.1   Chronic nasopharyngitis

    X.J30-J39.J31   Chronic rhinitis, nasopharyngitis and pharyngitis

    X.J30-J39.J31.2   Chronic pharyngitis

    X.J00-J06.J02   Acute pharyngitis

    X.J00-J06.J03   Acute tonsillitis

    X.J30-J39.J35.0   Chronic tonsillitis

    X.J00-J06.J04   Acute laryngitis and tracheitis

    X.J10-J18.J15   Bacterial pneumonia, not elsewhere classified

    X.J20-J22.J20   Acute bronchitis

    X.J40-J47.J42   Chronic bronchitis, unspecified

    X.J40-J47.J40   Bronchitis, not specified as acute or chronic

    XIV.N10-N16.N11   Chronic tubulointerstitial nephritis

    XIV.N10-N16.N10   Acute tubulointerstitial nephritis

    XIV.N30-N39.N30   Cystitis

    XIV.N30-N39.N34   Urethritis and urethral syndrome

    XIV.N40-N51.N41   Inflammatory diseases of the prostate

    Contraindications:

    Individual intolerance to β-lactam antibiotics: penicillins and cephalosporins.

    Carefully:

    Imbalance of electrolytes or fluid, a history of bronchial asthma, severe liver damage, malabsorption syndrome.

    Pregnancy and lactation:

    Recommendations for FDA - Category B. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

    Dosing and Administration:

    Use in children

    Inside in the form of a suspension once a day for 1-2 hours before or after a meal: from 9 mg / kg up to 400 mg per day.

    For children from 10 years of age and body weight over 45 kg, adult doses are used.

    Adults

    Inside, in the form of capsules, regardless of the time of ingestion, 200 mg twice a day.

    The highest daily dose: 400 mg.

    The highest single dose: 200 mg.

    Side effects:

    Central and peripheral nervous system: headache, dizziness.

    Hemopoietic system: leukopenia, thrombocytopenia, hemolytic anemia, eosinophilia, hypoprothrombinemia.

    Digestive system: nausea, vomiting, diarrhea, cholestatic jaundice, pseudomembranous colitis, increased activity of hepatic transaminases, hepatitis.

    Dermatological reactions: hyperhidrosis, rash, itching, candidiasis.

    Urinary system: interstitial nephritis.

    Allergic reactions.

    Overdose:

    Increased side effects.

    Treatment is symptomatic.
    Interaction:

    When used simultaneously with aminoglycosides, butadione, polymyxins, the risk of nephrotoxicity increases.

    Increase the effect of aminoglycosides, metronidazole, polymyxins, rifampicin, weaken - levomitsetin, tetracyclines.

    Reduces the bioavailability of histamine H blockers2-receptors (including ranitidine) and antacid preparations (aluminum hydroxide, sodium bicarbonate).

    Kolestyramin reduces the absorption of ceftibutene.

    Special instructions:

    During treatment, a false positive Coombs reaction and a false positive urine reaction to glucose are possible.

    Instructions
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