For oral administration. Suspension of Cedex® should be taken approximately 2 hours before or 1 hour after meals. Before using the preparation, the vial with the finished suspension should be vigorously shaken.
The duration of treatment with Cedex® is usually 5 to 10 days.
In the treatment of infections caused by Streptococcus pyogenes, Cedex® in
The therapeutic dose should be used for at least 10 days.
Adults. The recommended dose of Cedex® is 400 mg / day (11.1 ml
suspension per day).
In the treatment of acute bacterial sinusitis, exacerbation of chronic bronchitis and urinary tract infections (acute and chronic pyelitis, cystopyelitis, cystitis, urethritis), the drug can be used 400 mg once a day.
In the treatment of community-acquired pneumonia in patients who have oral therapy, the recommended dose is 200 mg (5.6 ml of suspension) every 12 hours. The duration of therapy is 5-10 days, depending on the severity and type of the disease.
Adult patients with impaired renal function. With mild renal insufficiency, the pharmacokinetics of the Cedex® preparation does not change significantly, so a dose change is required only when the creatinine clearance is less than 50 ml / min.
If the clearance of creatinine is 30 to 49 ml / min, then the daily dose should be reduced to 200 mg. With the clearance of creatine from 5 to 29 ml / min, the recommended daily dose is 100 mg (2.8 ml suspension).
If a change in the frequency of application is preferable, the 400 mg Cedex® preparation can be used every 48 hours (once every 2 days) with a creatinine clearance of 30-49 mL / min or every 96 hours (1 every 4 days) with creatinine clearance of 5 -29 ml / min. Patients on hemodialysis two or three times a week, Cedex® can be administered 400 mg at the end of each hemodialysis session.
Children. The recommended dose of the suspension for oral administration is 9 mg / kg / day (0.25 ml / kg / day), maximum 400 mg / day.
Children from 12 years of age and weighing 45 kg or more Cedex® can be used in the recommended adult dose.
In the treatment of pharyngitis, accompanied or not accompanied by tonsillitis, acute otitis media and urinary tract infections (acute and chronic pyelitis, cystopyelitis, cystitis, urethritis), the drug can be applied once a day. The duration of therapy is 5-10 days, depending on the severity and type of the disease.
The safety and effectiveness of Cedex® in children less than 6 months of age, including newborns, have not been established.
Preparation of a suspension for oral administration
Before opening the vial with powder, shake it. The powder can have a specific odor, which is not a sign of unfitness. After mixing the powder with water, the finished suspension acquires a characteristic cherry smell.
Measure the required amount of water (28 ml) by pouring water into a measuring cup (supplied) to the level of the hole. Pour approximately half of the measured water into the vial of powder and shake to moisten the powder well, then add the remaining amount of water to the vial and shake well again until the powder is completely dissolved and 33 ml of a homogeneous suspension is obtained.To dispense the prepared suspension it is recommended to use the measuring spoon included in the kit and having a calibration of 1.25 ml, 2.5 ml, 3.75 ml and 5 ml suspension, or other medical dosing product available to the patient.