Cytochrome C - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Antihypoxants and antioxidants

Included in the formulation

Cytochrome C

solution w / m in / in

SAMSON-MED, LLC Russia

АТХ:

C.01.C.X Other cardiotonic drugs

Pharmacodynamics:

Pharmacological action - antihypoxic, cytoprotective, stimulating cellular metabolism.

Improves the processes of tissue respiration. Stimulates oxidation-reduction processes in tissues due to the reversible transition of iron ions contained in the prosthetic group, from the oxidized state to the reduced state. As a result, endogenous oxidative reactions are accelerated, metabolic processes in tissues and oxygen utilization are improved. Has a protective effect in hypoxia of various genesis, ischemic tissue damage and other clinical situations associated with a sharp decrease in oxidative processes.

Pharmacokinetics:

Quickly and completely absorbed in any way of administration. Well penetrates into cells of organs and tissues.

Indications:

Parenteral. Conditions accompanied by tissue hypoxia (asphyxia of newborns, poisoning with hypnotic, carbon monoxide, methane, ischemic, dystrophic, infectious-inflammatory, toxic damage to the myocardium, hepatic insufficiency, chronic heart failure, cerebral and peripheral circulation disorders, chronic pneumonia, respiratory insufficiency, senile degeneration retina of the eye,prevention of tissue damage during general anesthesia, to support the body in the pre- and postoperative periods (for operations on the thorax). Asphyxia of newborns.

Inside. Viral hepatitis, prevention and elimination of undesirable effects of overload on the body.

Eye drops. Dystrophy of the cornea (primary and secondary), corneal opacity, keratitis (in the stage of epithelialization).

ICD-10

I.B15-B19.B19 Viral hepatitis, unspecified

VII.H15-H22.H16 Keratite

VII.H15-H22.H18.4 Degeneration of the cornea

VII.H15-H22.H17 Scars and opacity of the cornea

IX.I30-I52.I50.9 Heart failure, unspecified

IX.I60-I69.I67.9 Cerebrovascular disease, unspecified

X.J10-J18.J18 Pneumonia without clarification of the pathogen

X.J95-J99.J96 Respiratory failure, not elsewhere classified

XI.K70-K77.K72 Hepatic failure, not elsewhere classified

XVI.P20-P29.P21 Asphyxia in childbirth

XIX.T36-T50.T42 Poisoning with anticonvulsant, sedative, hypnotics, and anti-Parkinsonics

XIX.T51-T65.T59 Toxic effect of other gases, fumes and vapors

XIX.T51-T65.T58 Toxic effect of carbon monoxide

Contraindications:

Hypersensitivity, pregnancy and breastfeeding (for systemic use).

Carefully:

Patients who are predisposed to allergic reactions, it is recommended to carry out a test with the injection of 0.5-1 ml of cytochrome C diluted 1:10.

Pregnancy and lactation:

Category of recommendations for FDA is not defined. Qualitative controlled studies in animals and humans were not conducted. Do not apply!

There is no information on the penetration into breast milk. Do not apply!

Dosing and Administration:

Intravenous, intramuscular, orally, topically. The dosage regimen is individual, depending on the indications and the dosage form used.

Before parenteral application, a sample for individual tolerance is necessary: 0.25 mg (0.1 ml of 0.25% solution) is injected intradermally, and after 30 minutes of reaction (red face, hives, itching) proceed to treatment. Before the appointment of a second course, the biological sample must be repeated.

Intramuscularly (slowly): usually inject 10-20 mg 1-2 times a day for 10-14 days. In severe conditions, the drug is administered in a dose of 10-20 mg intravenously drip for 4-8 hours. The daily dose of 30-80 mg.

In heart diseases, the drug in the same dose is injected into 200 ml of isotonic sodium chloride solution or 5% glucose solution by intravenous drip at a rate of 30-40 drops per minute for 6-8 hours.Inside: 20 mg 4 times a day for 5-10 days (depending on the severity of hypoxia).

Locally, instilled in the conjunctival sac 1-2 drop 3-4 times a day.

Asphyxia of newborns: intravenously 4 ml in the umbilical vein in the first 2 min after birth.

Side effects:

Allergic reactions (hyperemia of the skin of the face, skin itching, urticaria); with rapid intravenous injection, chills with an increase in body temperature, with prolonged use - a change in the composition of peripheral blood, indicators of the blood coagulation system, detoxifying liver function; when applied in the form of eye drops - congestion hyperemia, short-term burning.

Overdose:

Not described. Treatment is symptomatic.

Interaction:

Not described.

Special instructions:

Do not use as the sole remedy for the treatment of these diseases.

Monitoring of allergic reactions.

Instructions

Cytochrome C (Cytochromum C)