Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
АТХ:B.05.A.A.07 Hydroxyethyl starch
Pharmacodynamics:Colloidal plasma-substituting drug. Binds and retains water, increasing the volume of circulating blood by 130-140% of the administered amount. Reduces the hematocrit, thereby improving the rheological properties of the blood. Reduces plasma viscosity and platelet aggregation, preventing their aggregation. Improves microcirculation, normalizes hemodynamics.
Pharmacokinetics:
After intravenous administration, it is distributed in the reticuloendothelial system, where it is cleaved with amylase.
The half-life is 24 hours. Elimination by the kidneys.
Indications:
It is used to replenish the volume of circulating blood, and also with hemodilution. It is used to prevent and treat hypovolemic shock in injuries, burns, and surgeries.
IV.E70-E90.E86 Reduction of the volume of the liquid
XVIII.R50-R69.R57.1 Hypovolemic shock
I.A30-A49.A41.9 Septicemia, unspecified
XVIII.R50-R69.R58 Bleeding, not elsewhere classified
XIX.T20-T32.T30 Thermal and chemical burns, unspecified
XIX.T80-T88.T81.0 Bleeding and hematoma complicating the procedure, not elsewhere classified
XXI.Z100.Z100 * CLASS XXII Surgical Practice
Contraindications:
Hypervolaemia, hyperhydration, renal failure, hemorrhagic diathesis, individual intolerance, children under 6 years of age.
Carefully:
Pulmonary edema, congestive heart failure, hypersensitivity.
Pregnancy and lactation:
Recommendations for FDA - Category C. It is used for emergency indications.
Dosing and Administration:Intravenously drip, with a speed of not more than 500 ml for 30 minutes, up to 20 ml / kg per day.
The highest daily dose: 20 ml / kg.
The highest single dose: 20 ml / kg.
Side effects:
Central and peripheral nervous system: dizziness, headache, insomnia, weakness, fatigue, trembling, paresthesia.
Respiratory system: bronchospasm, pulmonary edema.
The cardiovascular system: a feeling of palpitations, swelling.
Dermatological reactions: acne.
Allergic reactions.
Overdose:Increased side effects.
Treatment is symptomatic, discontinuation of the drug.
Interaction:
Increases the nephrotoxicity of aminoglycosides.
Pharmacologically incompatible with other medicines.
Special instructions:Control of the composition of peripheral blood, bleeding time and blood coagulation.
In the treatment it is not recommended to drive vehicles and work with moving mechanisms.