Intravenously.
The doses used to treat and prevent hypovolemia and shock.
The maximum daily dose:
6% solution: 33 ml / kg / day. (= 2500 ml per 75 kg body weight per day or = 2 g HES / kg / day).
10% solution: 20 ml / kg / day. (= 1500 ml per 75 kg of body weight per day or = 2 g of HES / kg / day). Maximum infusion rate:
6% solution: 20 ml / kg / hour (= 1500 ml per 75 kg body weight per hour or = 1.2 g HES / kg / h).
10% solution: 20 ml / kg / hour (= 1500 ml per 75 kg body weight per hour or 2 g HES / kg / hour).
In children under 10 years of age, the infusion rate should not exceed 15 ml / kg / h.
Children older than 12 years: the average daily dose is 33 ml / kg, the maximum daily dose is 33 ml / kg (2 g of hydroxyethyl starch per kg / day); children from 3 to 12 years, respectively - 15-20 ml / kg and 33 ml / kg.
Doses used to reduce the amount of donor blood during surgical operations (acute normovolemic hemodilution).
Simultaneous administration of Hayes sterile 6% in a ratio of 1: 1 (up to a hematocrit of at least 30%) is recommended for direct preoperative replacement of one's own blood.
Blood sampling: 2-3 times with 500 ml of own blood.
Daily dose: 2-3 infusions of 500 ml of Hayes sterile 6%.
The rate of blood sampling is 1000 ml for 15-30 min.
The rate of administration of Hayes sterile is 6% -1000 ml for 15-30 min.
Recommended doses for hemodilution therapy.
The criterion is the decrease in the hematocrit indicator, determined for each patient. Infusion of Hayes sterile 6%, 10% can be carried out isovolemically (with simultaneous selection of own blood) or hypervolemically (without selection of own blood) in small (250 ml), medium (500 ml) or high doses (twice 500 ml). Avoid hypervolemia with too rapid administration and too large doses of the drug, the limiting dose is 1.2 g HES / kg / day.
The following daily doses and rate of administration are used:
Daily dose:
-250 ml (low dose)
-500 ml (medium dose)
-2 times 500 ml per day (high dose)
Infusion rate:
-250 ml for 0.5-2 hours
-500 ml for 4-6 hours
-2 times 500 ml for 8-24 hours.
Duration of use.
Treatment and prevention of hypovolemia and shock:
The degree and duration of hypovolemia determine the daily dose and duration of application of Hayes sterile.
Reduction of the use of donor blood during surgical interventions (acute normovolemic hemodilution).
Acute normovolemic hemodilution is used once in surgical interventions. Repeated application of Hayes steril is possible at normal values of hematocrit (not lower than 30%). Therapeutic hemodilution. The use of Hayes Steril for hemodilution therapy is recommended for 10 days.