From the central nervous system: fainting, drowsiness, depression, neuropathy, amnesia, tremors, convulsions, reversible rear leukoencephalopathy syndrome, disturbances of cerebral circulation.
From the hematopoiesis: anemia, hypocoagulation, thrombocytopenia, neutropenia, erythroblastopenia.
From the skin: xeroderma, urticaria, acne, alopecia, dermatitis, pigmentation disorders, photosensitivity, bullous dermatitis, plantar-palmar syndrome eritrodizestezii, nail changes.
From the gastrointestinal tract: vomiting, nausea, diarrhea, inflammation of the mucous membranes in the mouth, ulceration of the upper gastrointestinal tract, pancreatitis, bowel obstruction, hepatitis, cholestasis, cholecystitis, gastritis, colitis, anal fissures, dysphagia, enterocolitis, violation of appetite.
From the respiratory system: shortness of breath, bronchospasm, pulmonary infiltrates, bronchial asthma, pulmonary edema, reticular asphyxia, cough, pleural effusion.
On the part of the reproductive system: gynecomastia, decreased libido, menstrual cycle disorders.
From the sense organs: dry eyes, vertigo, conjunctivitis, noise in the ears, distortion of taste.
From the cardiovascular system: angina pectoris, tachycardia, myocardial infarction, cardiomegaly, increase / decrease in blood pressure, hot flashes, ventricular tachycardia, pericarditis, acute coronary syndrome, lengthening of the interval QT on the ECG.
From the musculoskeletal system: muscle weakness, tendonitis, myositis, rhabdomyolysis.
Metabolic disorders: hyperuricemia, hypoalbuminemia.
Other: sepsis, herpetic infection, enterocolitis, hypersensitivity, fluid retention.