Active substancePiobacteriophagePiobacteriophage Similar drugsTo uncover Piobacteriophage complex solution locally inwards externally MICROGEN FGUP Scientific and Production Association Russia Piobacteriophage polyvalent purified solution locally inwards externally MICROGEN FGUP Scientific and Production Association Russia Sextapage® solution locally inwards externally MICROGEN FGUP Scientific and Production Association Russia Dosage form: & nbspSolution for oral, topical and topical administration Composition:In 1 ml of the drug contains the active substance - sterile filtrate of phage-lysates Staphylococcus, Enterococcus, Streptococcus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Klebsiella oxytoca, enteropathogenic Escherichia coli, Proteus vulgaris, P.mirabilis - up to 1 ml.Excipients: Preservative: 8-hydroxyquinoline sulfate 0.0001 g / ml (calculated content); or 8-hydroxyquinoline sulfate monohydrate 0.0001 g / ml (in terms of 8-hydroxyquinoline sulfate, the calculated content). Description:Bacteriophage is a transparent liquid of yellow color of different intensity with a specific taste of the nutrient medium, without bitterness. Pharmacotherapeutic group:MIBP - bacteriophage ATX: & nbspV.03.A Other different drugs Pharmacodynamics:The complex pyobacteriophage possesses the ability to specifically lyse bacteria of staphylococci, streptococci, enterococci, proteus, Klebsiella pneumonia and oxytoca, Pseudomonas aeruginosa and Escherichia coli. Indications:Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, Pseudomonas aeruginosa, Klebsiella, pathogenic E. coli of various serogroups, proteus with internal, rectal and external application. - Diseases of the ear, throat, nose, respiratory tract and lungs - inflammation of the sinuses of the nose, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;- surgical infections - wound suppuration, burns, abscess, phlegmon, furuncles, carbuncles, hydroadenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis; - urogenital infections - urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis;- post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcers and iridocyclitis;- enteral infections - gastroenterocolitis, cholecystitis, dysbacteriosis;- generalized septic diseases;- purulent-inflammatory diseases of newborns - omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc .;- other diseases caused by bacteria of staphylococci, streptococci,Enterococci, Proteus, Klebsiella pneumonia and Oxytoca, Pseudomonas and Escherichia coli.With a preventive purpose, the drug is used to treat operational and -five wounds, as well as to prevent nosocomial infections due to epidemic indications. An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen. Contraindications:None. Pregnancy and lactation:It is advisable to use the drug during pregnancy and during breastfeeding. Dosing and Administration:Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth, 7-20 days (according to clinical indications). Depending on the nature of the source of infection, the bacteriophage is used: 1. Locally in the form of irrigation, lotion and tamponization with liquid phage in an amount up to 200 ml, depending on the size of the affected area. When abscesses, the bacteriophage is injected into the cavity of the focus after removal of the pus by puncture. The amount of the drug administered should be somewhat less than the volume of the removed pus. When osteomyelitis after appropriate surgical treatment, a bacteriophage 10-20 ml is poured into the wound.2.Introduction into the cavity - pleural, articular and other limited cavities up to 100 ml of bacteriophage, after which capillary drainage is left, through which a bacteriophage is repeatedly introduced for several days. 3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. In case the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected through the cystostomy or nephrostomy 1-2 times a day for 20-50 ml in the bladder and 5-7 ml in the renal pelvis. 4. With purulent-inflammatory gynecological diseases, the drug is administered into the vagina, uterus in a dose of 5-10 ml once daily. 5. With purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. Bacteriophage is used to rinse, rinse, instill, inject wetted turund (leaving them for 1 hour). 6. With conjunctivitis and keratoconjunctivitis, the drug is injected 2-3 drops 4-5 times a day, with a purulent ulcer of the cornea - 4-5 drops, with purulent iridocyclitis, the drug is used 6-8 drops every 3 hours in combination with oral intake. 7. In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, as well as by insertion into the periodontal pockets of turuns impregnated with a pyobacteriophage on5-10 minutes. 8. When, intestinal forms of the disease, diseases of internal organs, dysbacteriosis, the bacteriophage is applied through the mouth and in the enema. Through the mouth, the bacteriophage is given 3 times a day on an empty stomach 1 hour before meals. In the form of enemas prescribed 1 time per day instead of one reception through the mouth. Recommended dosage of the drug Age Age Dose for 1 reception (in mm) through the mouth in the enema Before 6 months 5 10 From 6 months before 1 of the year 10 20 From 1 years before 3 years 15 30 C 3 before 8 years 20 40 From 8 years and older 30 50 The use of bacteriophages does not exclude the use of other antibacterial drugs. In the event that chemical antiseptics were used before the bacteriophage was used to treat wounds, the wound should be thoroughly washed with a sterile 0.9% solution of sodium chloride.Use of bacteriophage in children (up to 6 months) In sepsis, enterocolitis of newborns, including premature infants, the bacteriophage is used in the form of high enemas (through the gas pipe or catheter) 2-3 times a day (see Table). In the absence of vomiting and regurgitation, the use of the drug through the mouth is possible. In this case, it is mixed with breast milk. Perhaps a combination of rectal (in enemas) and oral (through the mouth) application of the drug. The course of treatment is 5-15 days.With relapsing course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis with intrauterine infection or the danger of nosocomial infection in newborns, the bacteriophage is used as an enema 2 times a day for 5-7 days. In the treatment of omphalitides, pyoderma, infected wounds, the drug is applied twice daily in the form of applications (the gauze wipe is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of the skin).Precautions for use. Before use, the bottle with a liquid bacteriophage should be shaken. Do not use clouding! Side effects:Not installed. Overdose:Symptoms of overdose are not established. Interaction:The use of the drug is possible in combination with other drugs, including antibiotics. Effect on the ability to drive transp. cf. and fur: Form release / dosage:Solution for oral, local and external use. Packaging:In vials of 20 ml, 100 ml. 8 bottles of 20 ml with instructions for use in the pack. 1 bottle of 100 ml with instructions for use in the pack. Storage conditions:Storage in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 ° C in a dry place protected from light and out of the reach of children. Freezing is not allowed. Shelf life:2 years. Do not use after the expiration date. Terms of leave from pharmacies:Without recipe Registration number:LS-000700 Date of registration:21.06.2010 The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia Manufacturer: & nbsp MICROGEN FGUP NGO Russia Information update date: & nbsp26.04.2013 Illustrated instructions × Illustrated instructions Instructions