Piobacteriophage polyvalent purified - instructions for use, dose, side effects, contraindications

Active substancePiobacteriophagePiobacteriophage

Similar drugsTo uncover

Piobacteriophage complex

solution locally inwards externally

MICROGEN FGUP Scientific and Production Association Russia

Piobacteriophage polyvalent purified

solution locally inwards externally

MICROGEN FGUP Scientific and Production Association Russia

Sextapage®

solution locally inwards externally

MICROGEN FGUP Scientific and Production Association Russia

Dosage form: & nbspSolution for oral, topical and topical administration

Composition:

In 1 ml of the drug contains the active substance - a sterile mixture of purified filtrate filtrates bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli.

Excipients: Preservative - 8-hydroxyquinoline sulfate - 0.0001 g / ml (calculated content); or 8-hydroxyquinoline sulfate monohydrate 0.0001 g / ml (in terms of 8-hydroxyquinoline sulfate, the calculated content).

Description:

The drug is a transparent liquid of yellow color of varying intensity, greenish gum is allowed.

Pharmacotherapeutic group:MIBP - bacteriophage

ATX: & nbsp

V.03.A Other different drugs

Pharmacodynamics:

Treatment and prevention of various forms of purulent-inflammatory and enteral diseases caused by Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli.

Indications:

- Diseases of the gastrointestinal tract (gastroenterocolitis, cholecystitis, pancreatitis, intestinal dysbacteriosis);

- inflammatory diseases of newborns and young children (gastroenterocolitis, intestinal dysbacteriosis, omphalitis, pemphigus, pyoderma, septicemia and septicopiaemia of various locations);

- surgical infections (suppuration of wounds, purulent skin lesions, burns, peritonitis, pleurisy, mastitis, osteomyelitis);

- urogenital infections (cystitis, pyelonephritis, endometritis, vulvitis, bartholinitis, colpitis, salpingoophoritis);

- purulent-inflammatory diseases of the ear, throat, nose, sinuses of the nose, mouth, pharynx, larynx, lungs and pleura (otitis, tonsillitis, pharyngitis, stomatitis, periodontitis, sinusitis, frontalitis, pneumonia, pleurisy);

- postgraumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcer and iridocyclitis;

- prevention of nosocomial infections caused by bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli.

An important condition for effective phage therapy is the preliminary determination of the pathogenicity of the pathogen.

Contraindications:

None.

Dosing and Administration:The drug is used for oral administration (through the mouth),in the form of enemas, applications, irrigation, the introduction of wounds in the cavity, vagina, uterus, nose, sinuses of the nose, as well as in the drained cavity: abscesses, abdominal, pleural, bladder, renal pelvis.
Inside, the drug is taken on an empty stomach for 0.5-1 hour before meals.

RECOMMENDED DOSAGE OF THE PREPARATION

AGE OF PATIENT	DOSE HAl RECEPTION with different methods of drug administration
AGE OF PATIENT	inwards (ml)	in enema (ml)
0-6 month	5	10
6-12 month	10	20
From 1 years before 3 years	15	20-30
From 3 before 8 years	20	30-40
From 8 years and older	20-30	40-50

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both topically and by taking the drug inside.
In the case of treatment of the purulent focus cavity with chemical antiseptics, before using the bacteriophage, it must be washed with a sterile 0.9% solution of sodium chloride.
In the treatment of angina, pharyngitis, laryngitis, the drug is used to rinse the mouth and throat 3 times a day for 10-20 ml, the course of treatment is 7-10 days.

When treating bronchitis, pneumonia, the drug is taken orally 3 times a day for 10-20 ml, and also used in the form of aerosols and inhalations (without heating and using ultrasound), the course of treatment is 15-20 days.

In the treatment of otitis, the drug is used to wash and insert into the middle ear cavity 2-5 ml 1-3 times a day. The course of treatment is 7-15 days.

When treating inflammation sinuses preparation is used for washing the nasal cavities, nasopharynx and sinuses in a dose of 5-10 ml, and introducing into the sinuses 2-3 ml. The procedure is repeated once daily for 7-10 days. In addition, the drug is injected into the nasal cavity in the form of turundas moistened with a bacteriophage, alternately in each nasal passage and left for 0.5-1 hour. The procedure is repeated 3 times a day, the course of treatment is 7-15 days.

In the treatment of periodontitis and chronic stomatitis preparation is used as a rinse oral 3-4 times a day at a dose of 10-20 ml, and the introduction into periodontal pockets turundae impregnated bacteriophage, 5-10 min, 7-10 days treatment.

With conjunctivitis and keratoconjunctivitis, the drug is applied 2-3 drops 4-5 times a day, the course of treatment is 5-7 days; in purulent corneal ulcer - 4-5 drops daily for 7-10 days in purulent iridocyclitis - 6-8 drops every 3 hours combined with ingestion of therapeutic doses for 7-10 days.

When abscess after opening and removal of pus preparation is administered in an amount less than the amount of remote pus once daily, 7-10 days treatment.

In peritonitis and pleurisy preparation is administered in -bryushnuyu drained cavity and the pleural drainage tube through a single daily dose of 20-70 ml, 10-15 days of treatment.

In osteomyelitis, the drug is injected into the wound cavity through turundas, drains in the amount of 10-30 ml once a day, the course of treatment is 15-20 days.
In the treatment of mastitis, suppuration of wounds and burns, the drug is used in the form of irrigation, applications, bandages, the introduction of a drainage in a dose of 5-50 ml, depending on the lesion at least once a day, the course of treatment 10-15 days.

In the treatment of purulent-inflammatory gynecological diseases (suppuration of wounds, endometritis, vulvitis, bartholinitis, colpitis, salpingo-oophoritis), the drug is used for irrigation, applications, injected into the wound cavity, vagina, uterus 5-20 ml once a day for 7-10 days.

With cystitis, pyelonephritis, the urethritis drug is taken orally at a therapeutic dose 3 times a day for 1 hour before meals for 10-20 days. In the event that the cavity of the bladder or renal pelvis is drained, the drug is injected through the cystostomy or nephrostomy 1-3 times a day for 20-50 ml in the bladder and 5-7 ml in the renal pelvis, the course of treatment is 7-15 days.

With gastroenterocolitis, pancreatitis, cholecystitis, as well as intestinal dysbiosis, the bacteriophage is taken orally at age dosages 3 times a day for 1 hour before meals for 7-15 days (according to clinical indications). With indomitable vomiting, the drug is used in the form of high enemas 2-3 times a day for 20-40 ml.With dysbacteriosis of the intestine, the drug can be used with preparations of normoflora.

For the prophylaxis of intrahospital surgical infections, the drug is used to treat postoperative and freshly infected wounds in a dose of 5-50 ml, depending on the lesion daily on a single dose for 5-7 days.

Use of the drug in children under 1 year (including premature infants).

With gastroenterocolitis, pneumonia and sepsis of newborns, the drug is administered through the mouth 2-3 times a day for 3-5 ml 30 minutes before feeding. In cases of uncontrollable vomiting, the drug is used in the form of high enemas (through a gas outlet tube or catheter) daily once in a dose of 5-10 ml. A combination of rectal (in the form of high enemas) and oral administration of the drug is possible. The course of treatment is 7-15 days (according to clinical indications). With a recurring course of the disease, repeated courses of treatment are possible.

In the treatment of omphalitis, pyoderma, infected wounds bacteriophage is used in the form of applications of 5-10 ml 2-3 times a day (a gauze cloth is moistened with a bacteriophage and applied to the umbilical cord or affected skin area) for 7-15 days.

In order to prevent the emergence of nosocomial infection in newborns, the bacteriophage is used for epidemiological indications inside by 3-5 ml 3 times a day 30 minutes before feeding during the entire period of stay in the hospital.

Side effects:Not installed.

Interaction:The use of the drug does not exclude the use of other antibacterial and anti-inflammatory drugs.

Special instructions:

Before use, the bacteriophage vial must be shaken and scanned. The drug should be clear and free of sediment.

Attention! In case of turbidity, do not use the drug!

If it is necessary to use a part of the bottle (small doses), remove the central part of the aluminum cap with tweezers or scissors, treat the exposed surface of the rubber plug with a cotton swab moistened with an alcohol-containing solution and draw the required dose of the drug with a sterile syringe. To select each dose of the drug from the vial, a new sterile syringe with a needle should be used. The drug from the opened bottle, subject to the above rules, storage conditions, and the absence of turbidity can be used for the entire shelf life.

Form release / dosage:

Solution for oral, local and external use.

Packaging:

For 4 or 10 bottles with instructions for use in a pack of cardboard.

4 bottles in a contour acrylic packing from a film of polyvinylchloride. 1 contour pack with instructions for use in a pack of cardboard.

Storage conditions:The drug is stored (inaccessible to children) and transported in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 ° C. Transportation at a temperature of 8 to 25 ° C is allowed for not more than 1 month.

Shelf life:Shelf life 2 years. The drug with expired shelf life is not subject to application.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002031

Date of registration:27.01.2012

The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Manufacturer: & nbsp

MICROGEN FGUP NGO Russia

Information update date: & nbsp28.05.2013

Illustrated instructions

Instructions

Piobacteriophage polyvalent purified (Pyobacteriophagum polyvalentum purum)