Intravenous, drip, with acute blood loss - intraarterially (in a hospital). The volume and speed of administration is determined by the patient's condition, blood pressure, heart rate, hematocrit.
Transfusion is performed in the usual way, following the rules of transfusion: before transfusion biological test (after the administration of 5-10 drops, a 3-minute break is made, then another 10-15 drops are added and after another break, if there are no symptoms of the reaction (heart rate increase, blood pressure decrease, skin hyperemia, difficulty breathing), continue the transfusion).
With developed shock or acute blood loss - intravenously, struino, 0.4-2 l (5-25 ml / kg). After increasing blood pressure to 80-90 mm Hg. usually pass to a drop introduction at a rate of 3-3.5 ml / min (60-80 cap / min). Possible intra-arterial route of administration (in the same dosages). Infusion of the drug should be carried out under constant control of the main indicators of systemic hemodynamics. With a significant increase in central venous pressure, reduce the dose and rate of administration or completely stop.
With blood loss of more than 500-750 ml and severe anemia, the patient is combined with a blood transfusion, erythrocytic mass or red blood cell suspension necessary to eliminate tissue hypoxia, as well as fresh-frozen plasma containing hemostatic system factors.
For the prevention of operational blood loss, as well as with the aim of achieving artificial hemodilution, preventing thrombosis and reducing the tendency to develop or progress the syndrome of desynvised intravascular coagulation the drug is administered in doses of 5-10 ml / kg (children - 10-15 ml / kg) for 30-60 minutes before surgery (in the case of a significant decrease in blood pressure go to the jet injection, with a drop in blood pressure below 60 mm Hg .- intra-arterially). The volume of infusion during surgery is determined by the magnitude of operational blood loss (hematocrit should not fall below 0.3).
In the postoperative period rapid infusion is an effective way to prevent shock.
With burn shock: in the first 24 hours, 2-3 liters are introduced, in the next 24 hours, 1.5 liters. Children in the first 24 hours - 40-50 ml / kg, the next day - 30 ml / kg.
With extensive and deep burns combined with the introduction of plasma, albumin, gamma globulin; with burns more than 30-40% of the body surface - with blood transfusion.
To prevent possible dehydration of tissues it is recommended to combine the infusion of the drug with the introduction of crystalloid solutions in a ratio of 1: 2.