Povidone-iodine + Potassium iodide (Povidonum-Iodum + Kalii iodidum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antiseptics and disinfectants

Included in the formulation
  • Yodopirone
    solution externally 
    YUZHFARM, LLC     Russia
  • Yodopirone
    powder externally 
    TROITSKY IODNY FACTORY, OJSC     Russia
    • АТХ:

    D.08.A.G.   Preparations of iodine

    Pharmacodynamics:

    Elementary iodine has pronounced antimicrobial properties. For preparations of elemental iodine, a pronounced local irritant effect on tissues is characteristic, and cauterizing effect in high concentrations. Local action is due to the ability of elementary iodine to precipitate tissue proteins. Preparations, eliminating the elementary iodine, have a much less pronounced irritant effect, and iodides have locally irritating properties only at very high concentrations.

    The nature of the resorptive action of preparations of elemental iodine and iodides is the same. The most pronounced effect with resorptive action iodine preparations have on the functions of the thyroid gland. With iodine deficiency, iodides contribute to the restoration of impaired thyroid hormone synthesis. With a normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, reduce the sensitivity of the thyroid gland to the TTG of the pituitary gland, and block its secretion by the pituitary gland. The effect of iodine preparations on metabolism is manifested by the intensification of dissimilation processes.With atherosclerosis, they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, increase the fibrinolytic and lipoproteinase activity of blood serum and slow the rate of blood clotting.

    Accumulating in syphilitic scales, iodine promotes their softening and resorption. However, the accumulation of iodine in tuberculosis foci leads to an intensification of the inflammatory process in them. Isolation of iodine excretory glands is accompanied by irritation of glandular tissue and increased secretion. This is due to expectorant action and stimulation of lactation (in small doses). However, in large doses of iodine preparations can cause suppression of lactation.

    Decrease pH negatively affects the effectiveness of the antimicrobial effect of the drug.

    Pharmacokinetics:

    Iodine is slightly absorbed from the surface of the skin, mucous membranes. Absorption is increased when there is damage. Excreted by the kidneys, with breast milk, then, saliva.

    Indications:
    • Wounds
    • Myalgia
    • Injuries
    • Fresh thermal and chemical burns I-II degree
    • Atrophic rhinitis
    • Purulent otitis media
    • Chronic tonsillitis
    • Trophic / varicose ulcers
    • Prevention / treatment of atherosclerosis
    • Tertiary syphilis

    Indications for use ointments: acute purulent diseases (phase I wound process), accompanied by abundant suppuration: postinjection abscesses, phlegmon, mastitis, panaritium, furuncle, carbuncle, suppurating atheroma, lipoma, paraproctitis; suppurative postoperative wounds in surgery, traumatology, obstetrics, gynecology, osteomyelitic phlegmon, purulent fistula, hydradenitis. Chronic purulent diseases: trophic ulcers, bedsores, chronic osteomyelitis, thermal burns.

    In proctology (preoperative preparation of the rectum, prevention of purulent complications after general proctology and plastic surgery)

    In obstetrics and gynecology (preoperative preparation, prevention of purulent complications, sanation of the birth canal, etc.).

    Solution It is used to disinfect the hands of the surgeon, surgical field, surgical gloves and elbow bends of donors.

    ICD-10

    IX.I70-I79.I70   Atherosclerosis

    IX.I80-I89.I83.2   Varicose veins of the lower extremities with ulcer and inflammation

    X.J30-J39.J31   Chronic rhinitis, nasopharyngitis and pharyngitis

    X.J30-J39.J35.0   Chronic tonsillitis

    XIII.M70-M79.M79.1   Myalgia

    XIX.T08-T14.T14.0   Superficial injury of unspecified area of ​​the body

    XIX.T08-T14.T14.1   Open wound of unspecified area of ​​the body

    XIX.T20-T32.T30   Thermal and chemical burns, unspecified

    Contraindications:
    • Hypersensitivity
    • Pulmonary tuberculosis
    • Nephroses
    • Furunculosis
    • Chronic pyoderma
    • TOurticaria
    • Children under 5 years
    • Jade
    • Adenomas (including the thyroid gland)
    • Acne
    • Hemorrhagic diathesis
    • Pregnancy
    • Breast-feeding

    Carefully:

    No data.

    Pregnancy and lactation:

    Category by FDA - D. The drug is contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Dosing regimen is individual.

    Outwardly, topically: solution, ointment, aerosol.

    Before applying aerosol can several times shake, remove the protective cap, put the nozzle on the valve stem, bring its end to the affected area and gently press the nozzle head. When pressed to the stop for 1-2 seconds from the bottle comes 50-100 ml of foam, which contains 0.5-1 g of iodovidone or iodopyrone. A balloon is not used upside down. In the treatment of burns and wounds, the foam is applied uniformly, 1-1.5 cm thick, 1-2 times a day.To prepare the rectum for the operation (in the evening) for 15-20 minutes before the operation and after its completion, inject 50-100 ml (1-2 clicks) of the foam, and then - for 5-7 days. In obstetrics and gynecology - in an amount of 50-100 ml. Before each use, the nozzle is rinsed with boiled water or boiled for 5 minutes.

    Solution (they are prepared immediately before use from 1% solution): 0.1% (active iodine) solutions (5 ml) are used as a cutaneous antiseptic for processing the hands of the surgeon; the operating field is wiped with a tissue moistened with a solution; with extensive burns the patient is immersed in a bath with a solution of 1:32 or 1:50 for 10-15 minutes.

    For complex treatment of purulent wounds, disinfection of the operating field and treatment of elbow bends of donors - 0.5 and 1% (active iodine) solutions of iodopyrone.

    Ointment: for the treatment of wound processes with an abundant purulent discharge is used after the surgical treatment of the purulent focus with the careful removal of all necrotic tissues, the elimination of all blind purulent fouling and the treatment of wounds with a 3% solution of hydrogen peroxide. Wounds are friable with gauze pads soaked in ointment. Change swabs daily until the termination of the inflammatory process, the appearance of granulation in the wound and marginal epithelization.The recommended expenditure of the ointment on 1 dressing, with a good individual tolerance, should not exceed 150-200 grams. With a prophylactic purpose for the wound and burn surface, and for the area of ​​postoperative sutures, the ointment is applied with a thin layer and covered with sterile gauze napkins. Dressing is carried out as needed.

    Side effects:

    For external use: rarely - skin irritation; with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).

    Ingestion: skin allergic reactions, tachycardia, nervousness, sleep disorders, excessive sweating, diarrhea (in patients older than 40 years).

    Overdose:

    Symptoms overdose: irritation in the application site.

    Treatment: symptomatic. Prolonged use (more than 7-10 days) can cause a phenomenon of iodine ("metallic" taste in the mouth, excessive salivation, swelling of the eyes or larynx, etc.), at the appearance of which it should stop using the drug and consult a doctor.

    When swallowing the solution: anuria, diarrhea, abdominal pain, nausea, vomiting, fever, thirst, shock, tachycardia, kidney failure,metabolic acidosis, death due to vascular insufficiency / aspiration pneumonia and pulmonary edema / epiglottis edema. Treatment - drink a starch / flour solution or milk every 15 minutes.

    Interaction:

    It is not compatible with disinfectants containing mercury, alkali salts, oxidants, substances with acid reaction.

    Alkaline or acidic medium, the presence of fat, pus, blood weaken antiseptic activity.

    Weaken the strugogenic and hypothyroid action of lithium preparations.

    Special instructions:

    Avoid contact with eyes.

    With prolonged use, the phenomena of iodism are possible.

    Does not affect the ability to drive and manage vehicles
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