Subcutaneously and intravenously.
Adults are usually prescribed under the skin for 0.5 mg (1 ml of solution) 1-2 times a day.
In the treatment of myasthenia gravis, prozerin can be administered in combination with aldosterone antagonists. Myasthenia gravis is treated for a long time. With the development of the myasthenic crisis, adults are given intravenously (with 0.9% sodium chloride solution) 0.5-1 ml of the solution, then under the skin in usual doses at small intervals. To enhance the action of Proserin sometimes injected under the skin in addition ephedrine - 1 ml of 5% solution. In other diseases, the duration of treatment is 25-30 days, if necessary, the course of treatment is repeated after 3-4 weeks break.
To stimulate childbirth, 0.5 mg (1 ml of solution) can be administered 1-2 times at intervals of 1 hour, simultaneously with the first injection, 1 mg (1 ml of 0.1% solution) of atropine is administered once under the skin.
To stop the effect of muscle relaxants, intravenously, atropine sulfate is administered at a dose of 0.5-0.7 mg (0.5-0.7 ml of 0.1% solution), expect a rapid pulse and after 1.5-2 minutes, intravenously 1, 5 mg (3 ml of solution) of Proserin. If the effect of this dose is insufficient, re-inject the same dose (with the appearance of bradycardia, an additional injection of atropine). In total, you can enter 5-6 mg (10-12 ml of solution) of Proserin for 20-30 minutes. During the procedure, adequate ventilation is provided.
Children under the skin appoint 0.05 mg (0.1 ml of solution) for 1 year of life, but not more than 0.75 ml of 0.05% solution per injection. Usually, the children of Prozerin are prescribed once a day, however, if necessary, the daily dose of the drug can be divided into 2-3 doses. Side effect
Hypersalivation; spastic reduction and strengthening of intestinal motility; nausea; vomiting; flatulence; diarrhea; headache; dizziness; weakness; loss of consciousness; drowsiness; miosis; visual impairment; arrhythmias; brady or tachycardia; atrioventricular block; nodal rhythm; nonspecific changes on the electrocardiogram; heart failure; lowering blood pressure; dyspnea; respiratory depression until the stop; bronchospasm; tremor; spasms and twitching of the skeletal musculature,including the fasciculation of the muscles of the tongue, convulsions; dysarthria; arthralgia; increased frequency of urination; profuse sweating; allergic reactions (redness of the face, rash, itching, anaphylaxis).
For the removal of side effects reduce the dose or stop the use of the drug, if necessary, introduce atropine (1 ml of a 0.1% solution), metocinium iodide or other anticholinergic drugs.