Method of administration: subcutaneously and intravenously.
Prozerin-Darnitsa should be injected intravenously very slowly. There must always be a ready-made solution of atropine to eliminate the arising severe cholinergic reactions.
For the treatment of motor disorders after brain injuries, paralysis, during the recovery period after the meningitis, poliomyelitis, encephalitis: Adults - 0.5-1-2 mg (0.5 mg - 1 ml 0.05% solution) 1-2 times a day, the maximum single dose - 2 mg, daily - 6 mg.
The course of treatment (except for myasthenia gravis) - 25-30 days, if necessary - again, after 3-4 weeks. Most of the total daily dose is administered in the daytime, when the patient is most fatigued.
With myasthenia gravis subcutaneously 0.5 mg per day; The course of treatment is long, with a change in the way of administration. With myasthenic crisis (with difficulty breathing and swallowing) - adults 0.5-1 ml 0.05% solution intravenously, then subcutaneously, with small intervals.
With postoperative atony of the intestine, bladder: for prevention, incl.postoperative urinary retention, subcutaneously, 0.25 mg as soon as possible after surgery, and repeatedly every 4 to 6 hours for 3-4 days; treatment of urine retention - subcutaneously 0.5 mg; if the urine does not depart within 1 hour, catheterization is carried out and after the bladder is emptied, injected every 3 hours, with only 5 injections.
With the weakness of labor: subcutaneously - 1 ml of 0.05% solution 1-2 times with a break of 1 hour (in combination with 1 ml of 0.1% solution of atropine, subcutaneously once, against the background of the first injection).
To eliminate residual neuromuscular disorders by nondepolarizing muscle relaxants (after the preliminary administration of atropine at a dose of 0.6-1.2 mg intravenously, before the pulse is increased to 80 beats / min), 0.5-2 mg is injected slowly slowly through 1 / 2-2 minutes. If necessary, injections are repeated (including atropine in the case of bradycardia) in a total dose of not more than 5-6 mg (10-12 ml) for 20-30 minutes; During the procedure, good ventilation is provided.
Children (only in a hospital with myasthenia gravis gravis) 0.05 mg (0.1 ml 0.05% solution) subcutaneously for 1 year of life per day, but not more than 3.75 mg (0.75 ml 0.05% solution) per injection.
Carefully prescribe against the background of m-holinoblokatorov, in children (with myasthenia) against neomycin, streptomycin,kanamycin and other antibiotics with antidepolarizing effect, local and some common anesthetics, antiarrhythmic drugs and a number of other drugs that disrupt the cholinergic transmission.
Application in pregnancy and lactation
Strictly controlled studies on the use of Prozerin-Darnitsa in pregnant women have not been conducted. The application is only possible if the benefit to the mother exceeds the risk to the fetus.
If you need to use Prozerin-Darnitsa during lactation, breast-feeding should be stopped.
Children
Children are used for myasthenia gravis gravis subcutaneously (only in a hospital setting) at the doses specified in the "Method of administration and dose" section.