Raunatin (Raunatine)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceRauwolfia alkaloidsRauwolfia alkaloids
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  • Raunatin
    pills inwards 
    HEALTH PHARMACEUTICAL COMPANY, LTD.     Ukraine
    • Dosage form: & nbsppills
    Composition:

    1 tablet contains:

    active substance: raunatin in terms of 100% alkaloid content - 2.0 mg; Excipients: granulated sugar - 36.4 mg, potato starch with a moisture content of 10% - 26.1 mg, glucose - 14.5 mg, calcium stearate - 0.4 mg, stearic acid 0.4 mg, vaseline oil 0.2 mg, 62.8634 mg of magnesium carbonate, 14.9472 mg of magnesium carbonate, 0.5376 mg of pigment titanium dioxide, low molecular weight polyvinylpyrrolidone, 0.4040 mg of sicovite Green Z2755 - 0,0262 mg, talc - 0,0160 mg, aerosil - 1.0816 mg, wax - 0.0620 mg, oil vaseline - 0.0620 mg.

    Description:

    coated tablets, light green, with a biconvex surface. Three layers are visible on the cross-section: light green and white - shell, yellowish-brown with white impregnations - nucleus.

    Pharmacotherapeutic group:antihypertensive agent
    ATX: & nbsp

    C.02.A.A.04   The amount of alkaloids Rauwolfia

    Pharmacodynamics:

    The preparation of vegetable origin, contains the sum of alkaloids from the roots of rauwolfia (reserpine, serpentine, aymalin, etc.). Has antihypertensive and antiarrhythmic action. Sedative influence is less pronounced than in reserpine, but according to the hypotensive effect, Raunatin is practically not inferior to reserpine,in some cases, it is better tolerated. The hypotensive effect develops more slowly than in the reserpine.

    Pharmacokinetics:

    Alkaloids of the drug are well absorbed from the gastrointestinal tract; the maximum concentration in the blood is observed after 1-3 hours after administration. Binding to blood proteins - 40-50%. Half-life is 50-170 hours; metabolism - in the intestine and liver. In the first 96 hours after ingestion, 8% of the dose is excreted in the urine, mainly in the form of metabolites, and 62% - through the intestine, mostly unchanged.

    Indications:

    Arterial hypertension I degree of severity.

    Contraindications:

    Increased individual sensitivity to the components of the drug; severe arterial hypotension, severe bradycardia, coronary artery insufficiency, organic myocardial lesions, aortic defects; peptic ulcer of the stomach and duodenum, nephrosclerosis; depression; fructose intolerance and glucose / galactose absorption impairment syndrome or sugarase / isomaltase deficiency, glucose-galactose malabsorption syndrome; age to 18 years.

    Carefully:

    Cardiac ischemia

    Pregnancy and lactation:

    The use of the drug during pregnancy and lactation is contraindicated, since the alkaloid reserpine penetrates the placenta and into breast milk. If you need to use the drug during lactation, breastfeeding should be discontinued.

    Dosing and Administration:

    Raunatin is prescribed to adults inside after eating. Treatment should be carried out under the supervision of a physician.

    In the first day the initial dose is usually 1 tablet at night, on the 2nd day - 1 tablet 2 times a day; on the third day - 1 tablet 3 times a day. The maximum daily dose is 6 tablets. After achieving a stable therapeutic effect (usually after 10-14 days), the dose is gradually reduced to 1-2 tablets per day. The course of treatment is 3-4 weeks, but in some cases, according to the indications, the drug is taken for a long time in a maintenance dose (1 tablet a day). Conducting repeated courses of treatment is possible on the recommendation of a doctor.

    Side effects:

    Possible allergic reactions, nausea, drowsiness, dry mucous membranes, swelling of the nasal mucosa, increased sweating, asthenia, bradycardia, pain in the heart, worsening of the course of angina pectoris, development of depression or weighting of its course, decreased libido.

    Overdose:

    Symptoms: sweating, general weakness and severe hypotension.In severe cases, after a short period of euphoria, drowsiness, depression, hypodynamia, Parkinsonism, loss of consciousness, coma develop.

    Treatment: washing the stomach, taking activated charcoal. Showing forced diuresis. With a marked decrease in blood pressure, with the collapse of the patient to lay with his legs elevated; If necessary, intravenous administration of rheopolyglucin or 1% phenylephrine with the addition of angiotensinamide, or 2% phenylephrine solution, is indicated. Adrenomimetic agents are prescribed with great care because of the risk of developing pulmonary edema. A 10% solution of sodium caffeine-benzoate was injected subcutaneously. The presence of severe respiratory depression or its delay a requires sucking mucus out of the respiratory tract, intubation and carrying out artificial ventilation, oxygen therapy.

    There are no specific antidotes for poisoning with raunatin and other preparations of rauwolfia.

    Interaction:

    The antihypertensive effect of raunatin is enhanced when used with other antihypertensive agents (thiazide diuretics, beta-adrenoblockers, angiotensin-converting enzyme inhibitors, blockers of "slow" calcium channels, etc.).Raunatin can be applied simultaneously or sequentially with other antihypertensive drugs.

    With caution appoint together with quinidine, guanetidine, cardiac glycosides, beta-adrenoblockers (the danger of increasing the severity of negative chrono- and dromotropic action). Reduces the effectiveness of anti-Parkinsonics and sympathomimetics. Raunatin increases the effect of alcohol and barbiturates on the central nervous system.

    Special instructions:

    Patients with ischemic heart disease may experience an increase in angina attacks. At occurrence of pains in the field of heart it is necessary to lower a dose of Raunatinum or to interrupt treatment (for 1-3 days), to consult with the doctor.

    Before the planned surgical interventions, the drug should be stopped a few days before the operation. In case of emergency surgery under general anesthesia, patients taking rhainatin need premedication with atropine.

    Do not use the drug before the electropulse therapy session.

    The dose should be reduced gradually.

    1 tablet of Raunatin contains 0.00 87 XE (bread units), the maximum daily dose is 0.05 XE.

    Effect on the ability to drive transp. cf. and fur:

    During the period of drug use, one should refrain from engaging in potentially dangerous activities requiring increased attention and speed of psychomotor reactions.

    Form release / dosage:

    Tablets coated with a coat of 2 mg.

    For 10 or 20 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil.

    Five 5-unit cell packs of 10 tablets or one out-of-the-box cell pack of 20 tablets, along with a medical instruction, are placed in a pack of cardboard.

    Packaging:

    For 10 or 20 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil.

    Five 5-unit cell packs of 10 tablets or one out-of-the-box cell pack of 20 tablets, along with a medical instruction, are placed in a pack of cardboard.

    Storage conditions:

    Keep in a dark place.

    Keep out of the reach of children.

    Shelf life:

    3 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-002671
    Date of registration:26.12.2011
    The owner of the registration certificate:HEALTH PHARMACEUTICAL COMPANY, LTD. HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine
    Manufacturer: & nbsp
    Information update date: & nbsphttp://grls.rosminzdrav.ru/Grls_View_v2.aspx?idReg=266152&t=
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