Intramuscularly, adults and children - 20 IU / kg (0.133 ml / kg), once. Dose should not be exceeded under any circumstances, t. The introduction of an immunoglobulin can partially suppress the production of its own antibodies. If the introduction is anatomically possible,the maximum permissible part of the dose of the drug should be injected by infiltration around the wound, and the remainder intramuscularly (in the upper outer quadrant of the buttock). The central part of the gluteal region should be avoided, since there is a risk of damage to the sciatic nerve.
At the same time, the first dose of a vaccine for the prevention of rabies (prepared on human diploid cell culture) is administered to another part of the body, preferably as far from the place of administration of the immunoglobulin as an antirabic (preferably in the deltoid muscle region).
If therapy is postponed for any reason, the drug should be administered no later than the eighth day after the first dose of the vaccine, regardless of the time interval between contact with the virus and the onset of therapy.
The drug can not be administered using the same syringe or in the same anatomical area of the body as the vaccine for the prevention of rabies.
To ensure good infiltration of the affected parts of the body in children (especially those with multiple injuries), the dose of the drug can be diluted 2-3 times in a 0.9% solution of sodium chloride.
Immunoglobulin anti-rabies should be administered exclusively in combination with a vaccine for the prevention of rabies.The only exception is those who have already been vaccinated with a vaccine to prevent rabies and tothenryx PThe presence of anti-rabies antibodies has been confirmed. These people should only get the vaccine.
The therapy should be discontinued if the animal remains healthy during the 10-day observation period or if the deceased animal does not have a rabies virus after appropriate laboratory tests.